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Iodophenpropit

From Wikipedia, the free encyclopedia
Iodophenpropit
Names
IUPAC name
3-(1H-imidazol-5-yl)propylN'-[2-(4-iodophenyl)ethyl]imidothiocarbamate
Other names
1-[3-(3H-imidazol-4-yl)propylthio]-N'-[2-(4-iodophenyl)ethyl]formamidine
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
MeSHIodophenpropit
UNII
  • InChI=1S/C15H19IN4S/c16-13-5-3-12(4-6-13)7-8-19-15(17)21-9-1-2-14-10-18-11-20-14/h3-6,10-11H,1-2,7-9H2,(H2,17,19)(H,18,20)
    Key: UBHYDQAARZKHEZ-UHFFFAOYSA-N
  • C1=CC(=CC=C1CCN=C(N)SCCCC2=CN=CN2)I
Properties
C15H19IN4S
Molar mass414.30763 g/mol
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound

Iodophenpropit is ahistamine antagonist which binds selectively to theH3 subtype. Its125Iradiolabelled form has been used for mapping the distribution of H3 receptors in animal studies.[1][2]

References

[edit]
  1. ^Jansen, FP; Wu, TS; Voss, HP; Steinbusch, HW; Vollinga, RC; Rademaker, B; Bast, A; Timmerman, H (1994)."Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, 125I-iodophenpropit, to rat brain".British Journal of Pharmacology.113 (2):355–62.doi:10.1111/j.1476-5381.1994.tb16995.x.PMC 1510107.PMID 7834183.
  2. ^Jansen, FP; Mochizuki, T; Maeyama, K; Leurs, R; Timmerman, H (2000). "Characterization of histamine H3 receptors in mouse brain using the H3 antagonist 125Iiodophenpropit".Naunyn-Schmiedeberg's Archives of Pharmacology.362 (1):60–7.doi:10.1007/s002100000227.PMID 10935534.S2CID 21293180.
H1
Agonists
Antagonists
H2
Agonists
Antagonists
H3
Agonists
Antagonists
H4
Agonists
Antagonists
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