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Alpha-taxilin

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From Wikipedia, the free encyclopedia

(Redirected fromInterleukin 14)

Protein-coding gene in the species Homo sapiens

TXLNA

Identifiers

Aliases

TXLNA, IL14, TXLN, IL-14, taxilin alpha

External IDs

OMIM:608676;MGI:105968;HomoloGene:14062;GeneCards:TXLNA;OMA:TXLNA - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p35.2	Start	32,179,675bp^[1]
Band	1p35.2	End	32,198,285bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4 D2.2\|4 63.26 cM	Start	129,519,871bp^[2]
Band	4 D2.2\|4 63.26 cM	End	129,534,858bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

stromal cell of endometrium

tendon of biceps brachii

right adrenal gland

left adrenal gland

right adrenal cortex

body of uterus

left adrenal cortex

right coronary artery

left uterine tube

anterior pituitary

Top expressed in

hand

ventricular zone

mandibular prominence

maxillary prominence

foot

genital tubercle

tail of embryo

epiblast

otolith organ

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	cytokine activity syntaxin binding protein binding high molecular weight B cell growth factor receptor binding
Cellular component	cytoplasm membrane extracellular region cytosol
Biological process	B cell activation cell population proliferation exocytosis regulation of signaling receptor activity cytokine-mediated signaling pathway
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


200081


109658

Ensembl


ENSG00000084652


ENSMUSG00000053841

UniProt


P40222


Q6PAM1

RefSeq (mRNA)


NM_175852 NM_001376857 NM_001376858 NM_001376859


NM_001005506 NM_001199695

RefSeq (protein)


NP_787048 NP_001363786 NP_001363787 NP_001363788


NP_001005506 NP_001186624

Location (UCSC)

Chr 1: 32.18 – 32.2 Mb

Chr 4: 129.52 – 129.53 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Alpha-taxilin also known asinterleukin-14 (IL-14) orhigh molecular weight B-cell growth factor (HMW-BCGF) is aprotein that in humans is encoded by theTXLNAgene.^[5]^[6]^[7]

Interleukin-14 is acytokine that controls the growth andproliferation of both normal and cancerous B cells.^[8] This molecule was also recently designated taxilin.^[9] IL-14 induces B-cell proliferation, inhibitsantibody secretion, and expands selected B-cell subgroups. Thisinterleukin is produced mainly byT cells and certainmalignant B cells.

Gene

[edit]

In murine models, two distincttranscripts are produced from opposite strands of theil14gene that are called IL-14α and IL-14β.^[10] Theil14 locus is near the gene forLCK onchromosome 1 in humans.

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000084652 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000053841 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H (Jun 2004). "Identification and characterization of taxilin isoforms".Biochem. Biophys. Res. Commun.319 (3):936–43.doi:10.1016/j.bbrc.2004.05.073.PMID 15184072.
^Nogami S, Satoh S, Nakano M, Terano A, Shirataki H (Nov 2003). "Interaction of taxilin with syntaxin which does not form the SNARE complex".Biochem. Biophys. Res. Commun.311 (4):797–802.doi:10.1016/j.bbrc.2003.10.069.PMID 14623251.
^"Entrez Gene: TXLNA taxilin alpha".
^Ambrus JL, Pippin J, Joseph A, Xu C, Blumenthal D, Tamayo A, Claypool K, McCourt D, Srikiatchatochorn A, Ford RJ (July 1993)."Identification of a cDNA for a human high-molecular-weight B-cell growth factor".Proc. Natl. Acad. Sci. U.S.A.90 (13):6330–4.Bibcode:1993PNAS...90.6330A.doi:10.1073/pnas.90.13.6330.PMC 46922.PMID 8327514.
^Nogami S, Satoh S, Nakano M, Shimizu H, Fukushima H, Maruyama A, Terano A, Shirataki H (January 2003)."Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells".Genes Cells.8 (1):17–28.doi:10.1046/j.1365-2443.2003.00612.x.PMID 12558796.
^Shen L, Zhang C, Wang T, Brooks S, Ford RJ, Lin-Lee YC, Kasianowicz A, Kumar V, Martin L, Liang P, Cowell J, Ambrus JL (October 2006)."Development of autoimmunity in IL-14alpha-transgenic mice".J. Immunol.177 (8):5676–86.doi:10.4049/jimmunol.177.8.5676.PMID 17015757.S2CID 86324456.

External links

[edit]

HumanTXLNA genome location andTXLNA gene details page in theUCSC Genome Browser.

Ambrus JL, Pippin J, Joseph A, et al. (1993)."Identification of a cDNA for a human high-molecular-weight B-cell growth factor".Proc. Natl. Acad. Sci. U.S.A.90 (13):6330–4.Bibcode:1993PNAS...90.6330A.doi:10.1073/pnas.90.13.6330.PMC 46922.PMID 8327514.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction".Anal. Biochem.236 (1):107–13.doi:10.1006/abio.1996.0138.PMID 8619474.
Ambrus JL, Pippin J, Joseph A, et al. (1996)."Identification of a cDNA for a human high molecular-weight B-cell growth factor".Proc. Natl. Acad. Sci. U.S.A.93 (15): 8154.PMC 38894.PMID 8755619.
Yu W, Andersson B, Worley KC, et al. (1997)."Large-Scale Concatenation cDNA Sequencing".Genome Res.7 (4):353–8.doi:10.1101/gr.7.4.353.PMC 139146.PMID 9110174.
Hartley JL, Temple GF, Brasch MA (2001)."DNA Cloning Using In Vitro Site-Specific Recombination".Genome Res.10 (11):1788–95.doi:10.1101/gr.143000.PMC 310948.PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001)."Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs".Genome Res.11 (3):422–35.doi:10.1101/gr.GR1547R.PMC 311072.PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001)."Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing".EMBO Rep.1 (3):287–92.doi:10.1093/embo-reports/kvd058.PMC 1083732.PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Nogami S, Satoh S, Nakano M, et al. (2003)."Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells".Genes Cells.8 (1):17–28.doi:10.1046/j.1365-2443.2003.00612.x.PMID 12558796.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway".Nat. Cell Biol.6 (2):97–105.doi:10.1038/ncb1086.PMID 14743216.S2CID 11683986.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004)."From ORFeome to Biology: A Functional Genomics Pipeline".Genome Res.14 (10B):2136–44.doi:10.1101/gr.2576704.PMC 528930.PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006)."The LIFEdb database in 2006".Nucleic Acids Res.34 (Database issue): D415–8.doi:10.1093/nar/gkj139.PMC 1347501.PMID 16381901.
Gregory SG, Barlow KF, McLay KE, et al. (2006)."The DNA sequence and biological annotation of human chromosome 1".Nature.441 (7091):315–21.Bibcode:2006Natur.441..315G.doi:10.1038/nature04727.PMID 16710414.
Shen L, Zhang C, Wang T, et al. (2007)."Development of autoimmunity in IL-14alpha-transgenic mice".J. Immunol.177 (8):5676–86.doi:10.4049/jimmunol.177.8.5676.PMID 17015757.S2CID 86324456.
Ewing RM, Chu P, Elisma F, et al. (2007)."Large-scale mapping of human protein–protein interactions by mass spectrometry".Mol. Syst. Biol.3 (1): 89.doi:10.1038/msb4100134.PMC 1847948.PMID 17353931.

Cell signaling:cytokines

By family

Chemokine

CCL	CCL1 CCL2/MCP1 CCL3/MIP1α CCL4/MIP1β CCL5/RANTES CCL6 CCL7 CCL8 CCL9 CCL11 CCL12 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18/PARC/DCCK1/AMAC1/MIP4 CCL19 CCL20 CCL21 CCL22 CCL23 CCL24 CCL25 CCL26 CCL27 CCL28
CXCL	CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17
CX3CL	CX3CL1
XCL	XCL1 XCL2

TNF

Interleukin

Type I
(grouped by
receptor
subunit)

γ chain	IL2/IL15 IL4/IL13 IL7 IL9 IL21
β chain	IL3 IL5 GMCSF
IL6 like/gp130	IL6 IL11 IL27 IL30 IL31 +non ILOSM LIF CNTF CTF1
IL12 family/IL12RB1	IL12 IL23 IL27 IL35
Other	IL14 IL16 IL32 IL34

Type II

IL10 family

Interferon

I	IFNA1 IFNA2 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA21 IFNB1 IFNK IFNW1
II	IFNG

Ig superfamily

IL17 family

IL17/IL25 (IL17A)

Other

By function/
cell

proinflammatory cytokine
- IL1
- TNFA

Monokine
Lymphokine
- T_h1
  - IFNγ
  - TNFβ
- T_h2
  - IL4
  - IL5
  - IL6
  - IL10
  - IL13

Interleukin receptor modulators

IL-1

Decoy receptors:Rilonacept (IL-1 Trap)

IL-2

IL-3

IL-4

Antagonists:Pitrakinra

Antibodies:Dupilumab
Pascolizumab

IL-5

Agonists:Interleukin 5

Antagonists:YM-90709

Antisense oligonucleotides:TPI ASM8

IL-6

Agonists:Atexakin alfa
Interleukin 6

IL-7

Agonists:Interleukin 7

IL-8

See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)here instead.

IL-9

Agonists:Interleukin 9

Antibodies:Enokizumab

IL-10

Agonists:Ilodecakin
Interleukin 10 (CSIF)

IL-11

Agonists:Interleukin 11 (AGIF)
Oprelvekin

IL-12

Agonists:Edodekin alfa
Interleukin 12

Antibodies:Briakinumab
Ustekinumab

IL-13

IL-15

Agonists:ALT-803
Interleukin 15

IL-17

Agonists:Interleukin 17 (A,B,C,D,E (interleukin 25),F)

IL-18

Binding proteins:IL18BP

IL-20

Antibodies:Fletikumab (against IL-20)

IL-21

Agonists:Denenicokin
Interleukin 21

Antibodies:NNC0114-0005
NNC0114-0006

IL-22

Agonists:Interleukin 22

Antibodies:Fezakinumab (against IL-22)

IL-23

Agonists:Interleukin 23 (SGRF)

IL-27

Agonists:Interleukin 27 (interleukin 30)

IL-28

IL-31

Agonists:Interleukin 31

IL1RL1

Agonists:Interleukin 33

IL1RL2

Agonists:Interleukin 36 (α,β,γ)
Interleukin 38

Antagonists:IL-36RA

Others

JAK	Seehere instead.
Others	Interleukin 14 (taxilin alpha, HMW-BCGF) Interleukin 16 (signals throughCD4) Interleukin 24 (signals throughIL-22Rα1/IL-20Rβ heterodimer) Interleukin 26 (signals throughIL-20Rα/IL-10Rβ heterodimer) Interleukin 32 Interleukin 34 (signals throughM-CSFR/CSF1R) Interleukin 35 Unsorted:Efavaleukin alfa Efineptakin alfa

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