Interleukin 9 receptor (IL9R) also known asCD129 (Cluster ofDifferentiation129) is atype I cytokine receptor. IL9R also denotes its humangene.[5]
The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects ofinterleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at thepseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[5]
Kimura Y, Takeshita T, Kondo M, et al. (1995). "Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex".Int. Immunol.7 (1):115–20.doi:10.1093/intimm/7.1.115.PMID7718508.
Kermouni A, Van Roost E, Arden KC, et al. (1996). "The IL-9 receptor gene (IL9R): genomic structure, chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes, and identification of IL9R pseudogenes at 9qter, 10pter, 16pter, and 18pter".Genomics.29 (2):371–82.doi:10.1006/geno.1995.9992.PMID8666384.
Little FF, Cruikshank WW, Center DM (2001). "Il-9 stimulates release of chemotactic factors from human bronchial epithelial cells".Am. J. Respir. Cell Mol. Biol.25 (3):347–52.doi:10.1165/ajrcmb.25.3.4349.PMID11588013.
Tsukadaira A, Okubo Y, Koyama S, et al. (2002). "Human bronchial epithelium expresses interleukin-9 receptors and releases neutrophil chemotactic factor".Exp. Lung Res.28 (2):123–39.doi:10.1080/019021402753462040.PMID11868823.S2CID26893804.
