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Interleukin-7 receptor-α

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens

IL7R
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

3DI2,3DI3,3UP1

Identifiers
AliasesIL7R, CD127, CDW127, IL-7R-alpha, IL7RA, ILRA, Interleukin-7 receptor-α, interleukin 7 receptor
External IDsOMIM:146661;MGI:96562;HomoloGene:1646;GeneCards:IL7R;OMA:IL7R - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for IL7R
Genomic location for IL7R
Band5p13.2Start35,852,695bp[1]
End35,879,603bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for IL7R
Genomic location for IL7R
Band15 A1|15 4.16 cMStart9,505,874bp[2]
End9,530,262bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lung

  • granulocyte

  • lymph node

  • lower lobe of lung

  • epithelium of nasopharynx

  • appendix

  • blood

  • thymus

  • upper lobe of left lung

  • gallbladder
Top expressed in
  • blood

  • mesenteric lymph nodes

  • spleen

  • thymus

  • tibiofemoral joint

  • subcutaneous adipose tissue

  • bone marrow

  • Paneth cell

  • pharynx

  • lumbar subsegment of spinal cord
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3575

16197

Ensembl

ENSG00000168685

ENSMUSG00000003882

UniProt

P16871

P16872

RefSeq (mRNA)

NM_002185

NM_008372
NM_001355680

RefSeq (protein)

NP_002176

NP_032398
NP_001342609

Location (UCSC)Chr 5: 35.85 – 35.88 MbChr 15: 9.51 – 9.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin-7 receptor subunit alpha (IL7R-α) also known asCD127 (Cluster ofDifferentiation127) is aprotein that in humans is encoded by theIL7Rgene.[5][6]

IL7R-α is atype I cytokine receptor and is a subunit of the functionalinterleukin-7 receptor andthymic stromal lymphopoietin (TSLP) receptors.

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000168685 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000003882 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^"Entrez Gene: IL7R interleukin 7 receptor".
  6. ^Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosman D, Dower SK, March CJ, Namen AE (March 1990). "Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily".Cell.60 (6):941–51.doi:10.1016/0092-8674(90)90342-C.PMID 2317865.S2CID 45181020.

Further reading

[edit]

External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

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