interleukin 2 receptor, gamma
Identifiers
Symbol	IL2RG
Alt. symbols	SCIDX1, IMD4, CD132
NCBI gene	3561
HGNC	6010
OMIM	308380
RefSeq	NM_000206
UniProt	P31785
Other data
Locus	Chr. Xq13
Search for Structures Swiss-model Domains InterPro

Theinterleukin-7 receptor is aprotein found on the surface ofcells. It is made up of two different smaller protein chains - i.e. it is aheterodimer, and consists of two subunits, interleukin-7 receptor-α (CD127) and common-γ chain receptor (CD132).^[2][3] The common-γ chain receptors is shared with various cytokines, includinginterleukin-2,-4,-9, and-15.^[4] Interleukin-7 receptor is expressed on various cell types, includingnaive andmemory T cells and many others.

Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known asV(D)J recombination^{[citation needed]}. This protein is also found to control the accessibility of a region of thegenome that contains theT-cell receptor gamma gene, bySTAT5 and histone acetylation^{[citation needed]}. Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).^[5]

Several diseases are associated with Interleukin-7 receptor includingT-cell acute lymphoblastic leukaemia,^[6]multiple sclerosis,^[7]rheumatoid arthritis andjuvenile idiopathic arthritis.^[8]

• Cluster of differentiation

• IL7R+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

• Genes on human chromosome 5
• Genes on human chromosome X
• Type I cytokine receptors

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