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Inolimomab

From Wikipedia, the free encyclopedia
Monoclonal antibody
Pharmaceutical compound
Inolimomab
Monoclonal antibody
TypeWhole antibody
SourceMouse
TargetCD25
Clinical data
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
 ☒NcheckY (what is this?)  (verify)

Inolimomab is amousemonoclonal antibody developed as animmunosuppressive drug againstgraft-versus-host disease. Its target is thealpha chain of theinterleukin-2 receptor.[1][2]

References

[edit]
  1. ^Piñana JL, Valcárcel D, Martino R, Moreno ME, Sureda A, Briones J, et al. (November 2006)."Encouraging results with inolimomab (anti-IL-2 receptor) as treatment for refractory acute graft-versus-host disease".Biology of Blood and Marrow Transplantation.12 (11):1135–1141.doi:10.1016/j.bbmt.2006.06.010.PMID 17085306.
  2. ^Dartois C, Freyer G, Michallet M, Hénin E, You B, Darlavoix I, et al. (2007)."Exposure-effect population model of inolimomab, a monoclonal antibody administered in first-line treatment for acute graft-versus-host disease".Clinical Pharmacokinetics.46 (5):417–432.doi:10.2165/00003088-200746050-00004.PMC 2760126.PMID 17465640.
Intracellular
(initiation)
Antimetabolites
Macrolides/
otherIL-2 inhibitors
IMiDs
JAK inhibitors
Intracellular
(reception)
IL-1 receptor antagonists
mTOR
Extracellular
Antibodies
Monoclonal
Serum target
(noncellular)
Cellular
target
Unsorted
Polyclonal
-cept (Fusion)
Unsorted
Immune system
Human
Mouse
Chimeric
Humanized
Chimeric + humanized
Interleukin
Human
Humanized
Veterinary
Inflammatorylesions
Mouse
IL-1
IL-2
IL-3
IL-4
IL-5
IL-6
IL-7
IL-8
  • See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)here instead.
IL-9
IL-10
IL-11
IL-12
IL-13
IL-15
IL-17
IL-18
IL-20
IL-21
IL-22
IL-23
IL-27
IL-28
IL-31
IL1RL1
IL1RL2
Others
JAK
Others
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