 | |
| Clinical data | |
|---|---|
| Routes of administration | Oral |
| ATC code | |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | High (rapid and complete absorption) |
| Metabolism | Glucuronidation |
| Eliminationhalf-life | 2.3 hours |
| Excretion | Renal |
| Identifiers | |
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| CAS Number | |
| PubChemCID | |
| DrugBank |
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| ChemSpider |
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| UNII | |
| KEGG |
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| ChEBI | |
| ChEMBL | |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.046.197 |
| Chemical and physical data | |
| Formula | C17H15NO3 |
| Molar mass | 281.311 g·mol−1 |
| 3D model (JSmol) | |
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| |
Indoprofen is anonsteroidal anti-inflammatory drug (NSAID). It was withdrawn worldwide in the 1980s after postmarketing reports of severegastrointestinal bleeding.[1]
A 2004 study usinghigh-throughput screening found indoprofen to increase production of thesurvival of motor neuron protein, suggesting it may provide insight into treatments forspinal muscular atrophies.[1][2]
Theisoindolone ring system forms the nucleus for thisprofen NSAID.
The nitro group in 2-(4-nitrophenyl)propionic acid (1) is reduced using iron and hydrochloric acid to give 2-(4-aminophenyl)propionic acid (2). Reaction withphthalic anhydride then gives thephthalimide (4). Treatment with zinc in acetic acid yields indoprofen afterreduction of one of theamide groups.[3][4][5]
| pyrazolones / pyrazolidines | |
|---|---|
| salicylates | |
| acetic acid derivatives and related substances | |
| oxicams | |
| propionic acid derivatives (profens) |
|
| n-arylanthranilic acids (fenamates) | |
| COX-2 inhibitors (coxibs) | |
| other | |
| NSAID combinations | |
Key:underline indicates initially developed first-in-class compound of specific group;#WHO-Essential Medicines;†withdrawn drugs;‡veterinary use. | |
 | Thisdrug article relating to themusculoskeletal system is astub. You can help Wikipedia byexpanding it. |
