Animplant is amedical device manufactured to replace a missing biological structure, support a damaged biological structure, or enhance an existing biological structure. For example, an implant may be a rod, used to strengthen weakbones. Medical implants are human-made devices, in contrast to atransplant, which is a transplantedbiomedical tissue. The surface of implants that contact the body might be made of abiomedical material such astitanium,silicone, orapatite depending on what is the most functional.[1] In 2018, for example, American Elements developed a nickel alloy powder for 3D printing robust, long-lasting, and biocompatible medical implants.[2] In some cases implants contain electronics, e.g.artificial pacemaker andcochlear implants. Some implants arebioactive, such assubcutaneous drug delivery devices in the form of implantable pills ordrug-eluting stents.[3]
Implants can roughly be categorized into groups by application:
Sensory andneurological implants are used for disorders affecting the major senses and the brain, as well as other neurological disorders. They are predominately used in the treatment of conditions such ascataract,glaucoma,keratoconus, and othervisual impairments;otosclerosis and otherhearing loss issues, as well asmiddle ear diseases such asotitis media; and neurological diseases such asepilepsy,Parkinson's disease, andtreatment-resistant depression. Examples include theintraocular lens,intrastromal corneal ring segment,cochlear implant,tympanostomy tube, andneurostimulator.[1][3][4]
Cardiovascular medical devices are implanted in cases where the heart, itsvalves, and the rest of thecirculatory system is in disorder. They are used to treat conditions such asheart failure,cardiac arrhythmia,ventricular tachycardia,valvular heart disease,angina pectoris, andatherosclerosis. Examples include theartificial heart,artificial heart valve,implantable cardioverter-defibrillator,artificial cardiac pacemaker, andcoronary stent.[1][3][4]
Orthopaedic implants help alleviate issues with the bones and joints of the body.[5] They are used to treatbone fractures,osteoarthritis,scoliosis,spinal stenosis, andchronic pain as well as inknee andhip replacements. Examples include a wide variety ofpins, rods, screws, and plates used to anchor fractured bones while they heal.[1][3][4]
Metallic glasses based on magnesium with zinc and calcium addition are tested as the potential metallic biomaterials for biodegradable medical implants.[6][7]
Patients with orthopaedic implants sometimes need to be put undermagnetic resonance imaging (MRI) machine for detailed musculoskeletal study. Therefore, concerns have been raised regarding the loosening and migration of implant, heating of the implant metal which could cause thermal damage to surrounding tissues, and distortion of the MRI scan that affects the imaging results. A study of orthopaedic implants in 2005 has shown that majority of the orthopaedic implants does not react with magnetic fields under the 1.0Tesla MRI scanning machine with the exception of external fixator clamps.[8] However, at 7.0 Tesla, several orthopaedic implants would show significant interaction with the MRI magnetic fields, such asheel andfibular implant.[9]
Electrical implants are being used to relieve pain fromrheumatoid arthritis.[10] The electric implant is embedded in the neck of patients with rheumatoid arthritics, the implant sends electrical signals to electrodes in thevagus nerve.[11][12] The application of this device is being tested an alternative to medicating people with rheumatoid arthritis for their lifetime.[13]
Contraceptive implants are primarily used to preventunintended pregnancy and treat conditions such as non-pathological forms ofmenorrhagia. Examples includecopper- andhormone-basedintrauterine devices.[3][4][14]
Cosmetic implants — oftenprosthetics — attempt to bring some portion of the body back to an acceptable aesthetic norm. They are used as a follow-up tomastectomy due tobreast cancer, for correcting some forms ofdisfigurement, and modifying aspects of the body (as inbuttock augmentation andchin augmentation). Examples include thebreast implant,nose prosthesis,ocular prosthesis, andinjectable filler.[1][3][4]
Other types oforgan dysfunction can occur in the systems of the body, including thegastrointestinal,respiratory, andurological systems. Implants are used in those and other locations to treat conditions such asgastroesophageal reflux disease,gastroparesis,respiratory failure,sleep apnea,urinary andfecal incontinence, anderectile dysfunction. Examples include theLINX,implantable gastric stimulator,diaphragmatic/phrenic nerve stimulator, neurostimulator,surgical mesh,artificial urinary sphincter andpenile implant.[3][4][15][16][17][18][19]
Drug‑eluting implants combine the structural benefits of traditional devices with advanced drug delivery systems, achieving controlled release through the use of specialized materials. These implants often harness biodegradable polymers—such as PLA, PGA, andPLGA—to precisely orchestrate drug release via mechanisms like diffusion, polymer degradation, and osmotic pressure, ensuring high local concentrations while minimizing systemic side effects. This sophisticated approach to controlled release not only tailors therapy to the specific needs of cardiovascular, ocular, and orthopedic applications but also leverages ongoing innovations in materials science and nanotechnology to create next‐generation, personalized implantable systems[20][21]
Medical devices are classified by the USFood and Drug Administration (FDA) under three different classes depending on the risks the medical device may impose on the user. According to 21CFR 860.3, Class I devices are considered to pose the least amount of risk to the user and require the least amount of control. Class I devices include simple devices such as arm slings and hand-heldsurgical instruments. Class II devices are considered to need more regulation than Class I devices and are required to undergo specific requirements before FDA approval. Class II devices include X-ray systems and physiological monitors. Class III devices require the most regulatory controls since the device supports or sustains human life or may not be well tested. Class III devices include replacementheart valves and implantedcerebellar stimulators. Many implants typically fall under Class II and Class III devices.[22][23]
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A variety of minimallybioreactive metals are routinely implanted. The most commonly implanted form ofstainless steel is316L.Cobalt-chromium andtitanium-based implant alloys are also permanently implanted. All of these aremade passive by a thin layer of oxide on their surface. A consideration, however, is that metal ions diffuse outward through the oxide and end up in the surrounding tissue. Bioreaction to metal implants includes the formation of a small envelope of fibrous tissue. The thickness of this layer is determined by the products being dissolved, and the extent to which the implant moves around within the enclosing tissue. Pure titanium may have only a minimal fibrous encapsulation. Stainless steel, on the other hand, may elicit encapsulation of as much as 2 mm.[24]
Porous implants are characterized by the presence of voids in the metallic or ceramic matrix. Voids can be regular, such as in additively manufactured (AM) lattices,[25] or stochastic, such as in gas-infiltrated production processes.[26] The reduction in the modulus of the implant follows a complex nonlinear relationship dependent on the volume fraction of base material and morphology of the pores.[27]
Experimental models exist to predict the range of modulus that stochastic porous material may take.[28] Above 10% vol. fraction porosity, models begin to deviate significantly. Different models, such as the rule of mixtures for low porosity, two-material matrices have been developed to describe mechanical properties.[29]
AM lattices have more predictable mechanical properties compared to stochastic porous materials and can be tuned such that they have favorable directional mechanical properties. Variables such as strut diameter, strut shape, and number of cross-beams can have a dramatic effect on loading characteristics of the lattice.[30] AM has the ability to fine-tune the lattice spacing to within a much smaller range than stochastically porous structures, enabling the future cell-development of specific cultures in tissue engineering.[31]
1) The elastic modulus of the implant is decreased, allowing the implant to better match the elastic modulus of the bone. The elastic modulus of cortical bone (~18 GPa) is significantly lower than typical solid titanium or steel implants (110 GPa and 210 GPa, respectively), causing the implant take up a disproportionate amount of the load applied to the appendage, leading to an effect calledstress shielding.
2) Porosity enables osteoblastic cells to grow into the pores of implants. Cells can span gaps of smaller than 75 microns and grow into pores larger than 200 microns.[26] Bone ingrowth is a favorable effect, as it anchors the cells into the implant, increasing the strength of the bone-implant interface.[32] More load is transferred from the implant to the bone, reducing stress shielding effects. The density of the bone around the implant is likely to be higher due to the increased load applied to the bone. Bone ingrowth reduces the likelihood of the implant loosening over time because stress shielding and corresponding bone resorption over extended timescales is avoided.[33] Porosity of greater than 40% is favorable to facilitate sufficient anchoring of the osteoblastic cells.[34]
Under ideal conditions, implants should initiate the desiredhost response. Ideally, the implant should not cause any undesired reaction from neighboring or distant tissues. However, the interaction between the implant and the tissue surrounding the implant can lead to complications.[1] The process of implantation of medical devices is subjected to the same complications that other invasive medical procedures can have during or after surgery. Common complications includeinfection,inflammation, andpain. Other complications that can occur include risk ofrejection from implant-inducedcoagulation andallergic foreign body response. Depending on the type of implant, the complications may vary.[1]
When the site of an implant becomes infected during or after surgery, the surrounding tissue becomes infected bymicroorganisms. Three main categories of infection can occur after operation. Superficial immediate infections are caused by organisms that commonly grow near or on skin. The infection usually occurs at the surgical opening. Deep immediate infection, the second type, occurs immediately after surgery at the site of the implant. Skin-dwelling and airbornebacteria cause deep immediate infection. These bacteria enter the body by attaching to the implant's surface prior to implantation. Though not common, deep immediate infections can also occur from dormant bacteria from previous infections of the tissue at the implantation site that have been activated from being disturbed during the surgery. The last type, late infection, occurs months to years after the implantation of the implant. Late infections are caused by dormantblood-borne bacteria attached to the implant prior to implantation. The blood-borne bacteria colonize on the implant and eventually get released from it. Depending on the type of material used to make the implant, it may be infused withantibiotics to lower the risk of infections during surgery. However, only certain types of materials can be infused with antibiotics, the use of antibiotic-infused implants runs the risk of rejection by the patient since the patient may develop a sensitivity to the antibiotic, and the antibiotic may not work on the bacteria.[35]
Inflammation, a common occurrence after any surgical procedure, is the body's response to tissue damage as a result of trauma, infection, intrusion of foreign materials, or localcell death, or as a part of animmune response. Inflammation starts with the rapid dilation of localcapillaries to supply the local tissue with blood. The inflow of blood causes the tissue to become swollen and may cause cell death. The excess blood, or edema, can activate pain receptors at the tissue. The site of the inflammation becomes warm from local disturbances of fluid flow and the increased cellular activity to repair the tissue or remove debris from the site.[35]
Implant-induced coagulation is similar to thecoagulation process done within the body to prevent blood loss from damaged blood vessels. However, the coagulation process is triggered fromproteins that become attached to the implant surface and lose their shapes. When this occurs, the protein changes conformation and different activation sites become exposed, which may trigger an immune system response where the body attempts to attack the implant to remove the foreign material. The trigger of the immune system response can be accompanied by inflammation. The immune system response may lead to chronic inflammation where the implant is rejected and has to be removed from the body. The immune system may encapsulate the implant as an attempt to remove the foreign material from the site of the tissue by encapsulating the implant infibrinogen andplatelets. The encapsulation of the implant can lead to further complications, since the thick layers of fibrous encapsulation may prevent the implant from performing the desired functions. Bacteria may attack the fibrous encapsulation and become embedded into the fibers. Since the layers of fibers are thick, antibiotics may not be able to reach the bacteria and the bacteria may grow and infect the surrounding tissue. In order to remove the bacteria, the implant would have to be removed. Lastly, the immune system may accept the presence of the implant and repair and remodel the surrounding tissue. Similar responses occur when the body initiates an allergic foreign body response. In the case of an allergic foreign body response, the implant would have to be removed.[36]
The many examples ofimplant failure includerupture of siliconebreast implants,hip replacement joints, andartificial heart valves, such as theBjork–Shiley valve, all of which have caused FDA intervention. The consequences of implant failure depend on the nature of the implant and its position in the body. Thus, heart valve failure is likely to threaten the life of the individual, while breast implant or hip joint failure is less likely to be life-threatening.[1][36][37]
Devices implanted directly in thegrey matter of the brain produce the highest quality signals, but are prone toscar-tissue build-up, causing the signal to become weaker, or even non-existent, as the body reacts to a foreign object in the brain.[38]
In 2018,Implant files, an investigation made byICIJ revealed that medical devices that are unsafe and have not been adequately tested were implanted in patients' bodies. In United Kingdom, Prof Derek Alderson, president of theRoyal College of Surgeons, concludes: "All implantable devices should be registered and tracked to monitor efficacy and patient safety in the long-term."[39]
Relevant info in the foiclass.zip file.
