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Imidazolylindole

From Wikipedia, the free encyclopedia

Imidazolylindoles are a group ofcyclized tryptamines in which theamine has beencyclized into animidazolinering. They includeAGH-107,AGH-192, andAH-494. These compounds are known to act asselectiveserotonin5-HT7 receptoragonists.[1][2][3]

Chemical structures of selected imidazolylindoles

See also

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References

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  1. ^Latacz G, Hogendorf AS, Hogendorf A, Lubelska A, Wierońska JM, Woźniak M, Cieślik P, Kieć-Kononowicz K, Handzlik J, Bojarski AJ (November 2018)."Search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1H-imidazol-5-yl)-1H-indole-5-carboxamides, low-basicity 5-HT7 receptor agonists".MedChemComm.9 (11):1882–1890.doi:10.1039/c8md00313k.PMC 6256855.PMID 30568756.
  2. ^Jakubowska K, Hogendorf AS, Gołda S, Jantas D (August 2024)."Neuroprotective and Neurite Outgrowth Stimulating Effects of New Low-Basicity 5-HT7 Receptor Agonists: In Vitro Study in Human Neuroblastoma SH-SY5Y Cells".Neurochem Res.49 (8):2179–2196.doi:10.1007/s11064-024-04159-z.PMC 11233329.PMID 38834845.
  3. ^Hogendorf AS, Hogendorf A, Popiołek-Barczyk K, Ciechanowska A, Mika J, Satała G, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Ponimaskin E, Schade S, Zeug A, Bijata M, Kubicki M, Kurczab R, Lenda T, Staroń J, Bugno R, Duszyńska B, Pilarski B, Bojarski AJ (May 2019)."Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers".Eur J Med Chem.170:261–275.doi:10.1016/j.ejmech.2019.03.017.PMID 30904783.


Tryptamines
4-Hydroxytryptamines
andesters/ethers
5-Hydroxy- and
5-methoxytryptamines
N-Acetyltryptamines
α-Alkyltryptamines
Cyclized tryptamines
Isotryptamines
Related compounds


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