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| Formula | C19H24N2 |
| Molar mass | 280.415 g·mol−1 |
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Ibogamine is ananti-convulsant,anti-addictive, CNS stimulantalkaloid found inTabernanthe iboga and Crepe Jasmine (Tabernaemontana divaricata).[1][2][3]Basic research related to howaddiction affects the brain has used this chemical.[4]
Ibogamine persistently reduced the self-administration of cocaine and morphine in rats.[5] The same study found that ibogamine (40 mg/kg) andcoronaridine (40 mg/kg) did not produce "anytremor effects in rats that differ significantly from saline control". While the related alkaloidsibogaine (20–40 mg/kg),harmaline (10–40 mg/kg) anddesethylcoronaridine (10–40 mg/kg) were "obviously tremorgenic".[5]
Like ibogaine, it has seems to have similar pharmacology. It has effects onKOR,[6]NMDAR,nAChR[7] and serotonin sites.[8] It also inhibits acetylcholinesterase and butyrylcholinesterase.[9]
Ibogamine can be prepared from one-step demethoxycarbonylation process throughcoronaridine.[10]
