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ITPR2

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From Wikipedia, the free encyclopedia

Protein-coding gene in humans

ITPR2

Identifiers

Aliases

ITPR2, CFAP48, IP3R2, ANHD, INSP3R2, inositol 1,4,5-trisphosphate receptor type 2

External IDs

OMIM:600144;MGI:99418;HomoloGene:37593;GeneCards:ITPR2;OMA:ITPR2 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12p11.23	Start	26,335,352bp^[1]
Band	12p11.23	End	26,833,194bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6 G3\|6 77.7 cM	Start	146,009,797bp^[2]
Band	6 G3\|6 77.7 cM	End	146,403,721bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

germinal epithelium

skin of thigh

epithelium of colon

skin of hip

sural nerve

liver

oral cavity

bone marrow cell

lactiferous duct

Top expressed in

Ileal epithelium

zygote

oocyte

primary oocyte

secondary oocyte

corneal stroma

thymus

blood

ankle joint

brown adipose tissue

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	calcium channel activity calcium-release channel activity calcium ion transmembrane transporter activity ion channel activity calcium ion binding phosphatidylinositol binding inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity scaffold protein binding inositol 1,4,5 trisphosphate binding
Cellular component	cytoplasm integral component of membrane endoplasmic reticulum membrane membrane receptor complex plasma membrane sarcoplasmic reticulum cell cortex platelet dense tubular network membrane sarcoplasmic reticulum membrane nucleus endoplasmic reticulum cytoplasmic vesicle membrane secretory granule membrane
Biological process	regulation of cardiac conduction response to hypoxia cellular response to ethanol regulation of insulin secretion ion transport platelet activation calcium ion transmembrane transport transmembrane transport inositol phosphate-mediated signaling cellular response to cAMP signal transduction calcium ion transport release of sequestered calcium ion into cytosol transport
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


3709


16439

Ensembl


ENSG00000123104


ENSMUSG00000030287

UniProt


Q14571


Q9Z329

RefSeq (mRNA)


NM_002223


NM_010586 NM_019923

RefSeq (protein)


NP_002214


NP_034716 NP_064307

Location (UCSC)

Chr 12: 26.34 – 26.83 Mb

Chr 6: 146.01 – 146.4 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Inositol 1,4,5-trisphosphate receptor, type 2, also known asITPR2, is aprotein which in humans is encoded by theITPR2gene.^[5] Theprotein encoded by this gene is both areceptor forinositol triphosphate and acalcium channel.^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000123104 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000030287 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: inositol 1".
^Yamamoto-Hino M, Sugiyama T, Hikichi K, et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors".Recept. Channels.2 (1):9–22.PMID 8081734.

External links

[edit]

ITPR2+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

Membrane transport protein:ion channels (TC 1A)

Ca²⁺:Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺:Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺:Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻:Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺:Proton channel	HVCN1
M⁺:CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺:TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+solutes):Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm:Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin