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Integrin alpha 2b

From Wikipedia, the free encyclopedia
(Redirected fromITGA2B)

Mammalian protein found in Homo sapiens
ITGA2B
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1DPK,1DPQ,1KUP,1KUZ,1M8O,1S4W,1TYE,2K1A,2K9J,2KNC,2MTP,2VC2,2VDK,2VDL,2VDM,2VDN,2VDO,2VDP,2VDQ,2VDR,3FCS,3FCU,3NID,3NIF,3NIG,3T3M,3T3P,3ZDX,3ZDY,3ZDZ,3ZE0,3ZE1,3ZE2,4CAK,4Z7O,4Z7Q,5HDB,4Z7N

Identifiers
AliasesITGA2B, BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93, integrin subunit alpha 2b, GT1
External IDsOMIM:607759;MGI:96601;HomoloGene:37304;GeneCards:ITGA2B;OMA:ITGA2B - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for ITGA2B
Genomic location for ITGA2B
Band17q21.31Start44,372,180bp[1]
End44,389,649bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for ITGA2B
Genomic location for ITGA2B
Band11 D|11 66.29 cMStart102,344,123bp[2]
End102,360,948bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • blood

  • trabecular bone

  • granulocyte

  • pancreatic ductal cell

  • gonad

  • testicle

  • right hemisphere of cerebellum

  • bone marrow cells

  • sperm
Top expressed in
  • blood

  • tibiofemoral joint

  • embryo

  • yolk sac

  • spleen

  • lip

  • body of femur

  • right kidney

  • gastrula

  • granulocyte
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3674

16399

Ensembl

ENSG00000005961

ENSMUSG00000034664

UniProt

P08514

Q9QUM0

RefSeq (mRNA)

NM_000419

NM_010575

RefSeq (protein)

NP_000410

NP_034705

Location (UCSC)Chr 17: 44.37 – 44.39 MbChr 11: 102.34 – 102.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Integrin alpha-IIb is aprotein that in humans is encoded by theITGA2Bgene. ITGA2B, also known asCD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result inthrombasthenia. At least 38 disease-causing mutations in this gene have been discovered.[5] In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.[6]

Interactions

[edit]

ITGA2B has been shown tointeract withAUP1[7] andCLNS1A.[8]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000005961 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000034664 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Šimčíková D, Heneberg P (December 2019)."Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases".Scientific Reports.9 (1): 18577.Bibcode:2019NatSR...918577S.doi:10.1038/s41598-019-54976-4.PMC 6901466.PMID 31819097.
  6. ^"Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)".
  7. ^Kato A, Kawamata Norihiko, Tamayose Kenji, Egashira Motoki, Miura Rika, Fujimura Tsutomu, Murayama Kimie, Oshimi Kazuo (Aug 2002)."Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3".J. Biol. Chem.277 (32). United States:28934–41.doi:10.1074/jbc.M204340200.ISSN 0021-9258.PMID 12042322.
  8. ^Larkin D, Murphy Derek, Reilly Dermot F, Cahill Martha, Sattler Ellen, Harriott Pat, Cahill Dolores J, Moran Niamh (Jun 2004)."ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation".J. Biol. Chem.279 (26). United States:27286–93.doi:10.1074/jbc.M402159200.ISSN 0021-9258.PMID 15075326.

Further reading

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External links

[edit]
PDB gallery
  • 1txv:
    1txv:
  • 1ty3:
    1ty3:
  • 1ty5:
    1ty5:
  • 1ty6:
    1ty6:
  • 1ty7:
    1ty7:
  • 1tye: Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen
    1tye: Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen
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Coagulation factors
Primary hemostasis
(platelet activation)
Intrinsic pathway
(contact activation)
Extrinsic pathway
(tissue factor)
Common pathway
Anticoagulant factors
Fibrinolytic factors
Coagulation markers
Platelet activation
Thrombin generation
Fibrin generation
Fibrinolysis
Stub icon

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