Movatterモバイル変換

[0]ホーム
URL:

Jump to content
WikipediaThe Free Encyclopedia
Search

IONIS-GCCRRx

From Wikipedia, the free encyclopedia
Investigational antisense oligonucleotide
Pharmaceutical compound
IONIS-GCCRRx
Clinical data
Other namesISIS-426115; ISIS-GCCRRx
Drug classAntiglucocorticoid
Identifiers
  • all-P-ambo-2'-O-(2-methoxyethyl)-P-thioguanylyl-(3'→5')-2'-O-(2-methoxyethyl)-5-methyl-P-thiocytidylyl-(3'→5')-2'-O-(2-methoxyethyl)-P-thioadenylyl-(3'→5')-2'-O-(2-methoxyethyl)-P-thioguanylyl-(3'→5')-2'-O-(2-methoxyethyl)-5-methyl-P-thiocytidylyl-(3'→5')-2'-deoxy-5-methyl-P-thiocytidylyl-(3'→5')-2'-deoxy-P-thioadenylyl-(3'→5')-P-thiothymidylyl-(3'→5')-2'-deoxy-P-thioguanylyl-(3'→5')-2'-deoxy-P-thioguanylyl-(3'→5')-P-thiothymidylyl-(3'→5')-2'-deoxy-P-thioguanylyl-(3'→5')-2'-deoxy-P-thioadenylyl-(3'→5')-P-thiothymidylyl-(3'→5')-2'-deoxy-5-methyl-P-thiocytidylyl-(3'→5')-2'-O-(2-methoxyethyl)-P-thioadenylyl-(3'→5')-2'-O-(2-methoxyethyl)-P-thioguanylyl-(3'→5')-2'-O-(2-methoxyethyl)-P-thioguanylyl-(3'→5')-2'-O-(2-methoxyethyl)-P-thioadenylyl-(3'→5')-2'-O-(2-methoxyethyl)guanosine
PubChem SID
UNII
Chemical and physical data
FormulaC230H312N83O117P19S19
Molar mass7309.13 g·mol−1
  • COCCO[C@H]1[C@@H](O[C@@H]([C@H]1OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N1C(=O)N=C(N)C(=C1)C)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N1C=NC=2C(N)=NC=NC12)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N1C=NC=2C(=O)NC(N)=NC12)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N1C(=O)N=C(N)C(=C1)C)OCCOC)OP(=S)(O)OC[C@@H]1[C@H](C[C@@H](O1)N1C(=O)N=C(N)C(=C1)C)OP(=S)(O)OC[C@@H]1[C@H](C[C@@H](O1)N1C=NC=2C(N)=NC=NC12)OP(=S)(O)OC[C@@H]1[C@H](C[C@@H](O1)N1C(=O)NC(=O)C(C)=C1)OP(=S)(O)OC[C@@H]1[C@H](C[C@@H](O1)N1C=NC=2C(=O)NC(N)=NC12)OP(=S)(O)OC[C@@H]1[C@H](C[C@@H](O1)N1C=NC=2C(=O)NC(N)=NC12)OP(=S)(O)OC[C@@H]1[C@H](C[C@@H](O1)N1C(=O)NC(=O)C(C)=C1)OP(=S)(O)OC[C@@H]1[C@H](C[C@@H](O1)N1C=NC=2C(=O)NC(N)=NC12)OP(=S)(O)OC[C@@H]1[C@H](C[C@@H](O1)N1C=NC=2C(N)=NC=NC12)OP(=S)(O)OC[C@@H]1[C@H](C[C@@H](O1)N1C(=O)NC(=O)C(C)=C1)OP(=S)(O)OC[C@@H]1[C@H](C[C@@H](O1)N1C(=O)N=C(N)C(=C1)C)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N1C=NC=2C(N)=NC=NC12)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N1C=NC=2C(=O)NC(N)=NC12)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N1C=NC=2C(=O)NC(N)=NC12)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N1C=NC=2C(N)=NC=NC12)OCCOC)OP(=S)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N1C=NC=2C(=O)NC(N)=NC12)OCCOC)O)CO)N1C=NC=2C(=O)NC(N)=NC12
  • InChI=1S/C230H312N83O117P19S19/c1-93-48-294(224(327)271-173(93)231)130-38-100(416-440(343,459)384-67-124-157(167(367-32-22-357-12)209(406-124)306-85-260-142-179(237)250-77-255-184(142)306)426-446(349,465)389-72-128-162(172(372-37-27-362-17)215(410-128)313-92-270-152-194(313)282-223(247)290-205(152)326)430-449(352,468)391-74-129-161(171(371-36-26-361-16)214(411-129)312-91-269-151-193(312)281-222(246)289-204(151)325)429-448(351,467)388-70-125-158(168(368-33-23-358-13)210(407-125)307-86-261-143-180(238)251-78-256-185(143)307)425-442(345,461)383-66-121-153(315)163(363-28-18-353-8)206(403-121)309-88-266-148-190(309)278-219(243)286-201(148)322)111(392-130)56-373-431(334,450)413-102-40-132(296-52-97(5)195(316)291-228(296)331)394-112(102)57-374-436(339,455)418-106-44-136(302-81-259-141-178(236)249-76-254-183(141)302)398-117(106)61-378-438(341,457)420-108-46-138(304-83-264-146-188(304)276-217(241)284-199(146)320)399-118(108)62-379-434(337,453)415-104-42-134(298-54-99(7)197(318)293-230(298)333)396-114(104)59-376-437(340,456)419-107-45-137(303-82-263-145-187(303)275-216(240)283-198(145)319)401-120(107)64-381-439(342,458)421-109-47-139(305-84-265-147-189(305)277-218(242)285-200(147)321)400-119(109)63-380-433(336,452)414-103-41-133(297-53-98(6)196(317)292-229(297)332)395-113(103)58-375-435(338,454)417-105-43-135(301-80-258-140-177(235)248-75-253-182(140)301)397-116(105)60-377-432(335,451)412-101-39-131(295-49-94(2)174(232)272-225(295)328)393-115(101)65-382-441(344,460)423-155-123(405-207(165(155)365-30-20-355-10)299-50-95(3)175(233)273-226(299)329)69-386-445(348,464)428-160-127(409-213(170(160)370-35-25-360-15)311-90-268-150-192(311)280-221(245)288-203(150)324)73-390-447(350,466)427-159-126(408-211(169(159)369-34-24-359-14)308-87-262-144-181(239)252-79-257-186(144)308)71-387-444(347,463)424-156-122(404-208(166(156)366-31-21-356-11)300-51-96(4)176(234)274-227(300)330)68-385-443(346,462)422-154-110(55-314)402-212(164(154)364-29-19-354-9)310-89-267-149-191(310)279-220(244)287-202(149)323/h48-54,75-92,100-139,153-172,206-215,314-315H,18-47,55-74H2,1-17H3,(H,334,450)(H,335,451)(H,336,452)(H,337,453)(H,338,454)(H,339,455)(H,340,456)(H,341,457)(H,342,458)(H,343,459)(H,344,460)(H,345,461)(H,346,462)(H,347,463)(H,348,464)(H,349,465)(H,350,466)(H,351,467)(H,352,468)(H2,231,271,327)(H2,232,272,328)(H2,233,273,329)(H2,234,274,330)(H2,235,248,253)(H2,236,249,254)(H2,237,250,255)(H2,238,251,256)(H2,239,252,257)(H,291,316,331)(H,292,317,332)(H,293,318,333)(H3,240,275,283,319)(H3,241,276,284,320)(H3,242,277,285,321)(H3,243,278,286,322)(H3,244,279,287,323)(H3,245,280,288,324)(H3,246,281,289,325)(H3,247,282,290,326)/t100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110+,111+,112+,113+,114+,115+,116+,117+,118+,119+,120+,121+,122+,123+,124+,125+,126+,127+,128+,129+,130+,131+,132+,133+,134+,135+,136+,137+,138+,139+,153+,154+,155+,156+,157+,158+,159+,160+,161+,162+,163+,164+,165+,166+,167+,168+,169+,170+,171+,172+,206+,207+,208+,209+,210+,211+,212+,213+,214+,215+,431?,432?,433?,434?,435?,436?,437?,438?,439?,440?,441?,442?,443?,444?,445?,446?,447?,448?,449?/m0/s1
  • Key:JXMOHJNPGFEHIA-CHGQRGNJSA-N

IONIS-GCCRRx, also known asISIS-426115, is anantiglucocorticoid which is under development byIonis Pharmaceuticals for the treatment ofdiabetes mellitus type 2.[1][2] It has also been under investigation for the treatment ofCushing's syndrome, but no development has been reported.[1] The drug is anantisense oligonucleotide against theglucocorticoid receptor.[1] As of December 2017, it is inphase IIclinical trials for diabetes mellitus type 2.[1]

References

[edit]
  1. ^abcd"IONIS GCCRRx".AdisInsight. Springer Nature Switzerland AG.
  2. ^Chikara G, Sharma PK, Dwivedi P, Charan J, Ambwani S, Singh S (April 2018)."A Narrative Review of Potential Future Antidiabetic Drugs: Should We Expect More?".Indian Journal of Clinical Biochemistry.33 (2):121–131.doi:10.1007/s12291-017-0668-z.PMC 5891460.PMID 29651202.
GRTooltip Glucocorticoid receptor
Agonists
Mixed
(SEGRMsTooltip Selective glucocorticoid receptor agonists)
Antagonists
Others
Stub icon

Thishormonal preparation article is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=IONIS-GCCRRx&oldid=1308721537"
Categories:
Hidden categories:
[8]ページ先頭
©2009-2025 Movatter.jp