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INDV-1000

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Pharmaceutical compound

INDV-1000
Clinical data
Other names	INDV1000
Routes of administration	Unspecified^[1]
Drug class	GABA_B receptor positive allosteric modulator

INDV-1000 is aGABA_B receptor positive allosteric modulator (PAM) which is under development for the treatment ofsubstance-related disorders.^[1]^[2]^[3] Itsroute of administration is unspecified.^[1] The drug is under development by Indivior in partnership with Addex Therapeutics.^[1]^[2]^[3] As of April 2024, it is in thepreclinical research stage of development.^[1]^[2]^[3] Thechemical structure of INDV-1000 does not yet appear to have been disclosed.^[1] It is one of a limited number of known GABA_B receptor PAMs as of 2024.^[4]^[5]

See also

References

^^a ^b ^c ^d ^e ^f"INDV 1000".AdisInsight. 29 February 2024. Retrieved28 January 2026.
^^a ^b ^c"Delving into the Latest Updates on INDV-1000 with Synapse".Synapse. 27 May 2025. Retrieved28 January 2026.
^^a ^b ^cDeswal P (30 April 2024)."Addex stock tanks after lead drug flops in Phase II epilepsy trial".Clinical Trials Arena. Retrieved28 January 2026.Addex has also partnered with Indivior and is developing the gamma-aminobutyric acid subtype B (GABA-B) PAM asset, INDV-1000. The therapy is in preclinical development, with plans to select drug candidates for an investigational new drug (IND), enabling studies in June for the substance use disorder and chronic cough programs.
^Colombo G (March 2024). "Positive allosteric modulators of the GABAB receptor: a new class of ligands with therapeutic potential for alcohol use disorder".Alcohol and Alcoholism.59 (3) agae018.doi:10.1093/alcalc/agae018.PMID 38566580.
^Mugnaini C, Corelli F (2024)."Recent Advances on the Chemistry of GABAB Receptor Allosteric Modulators".GABAB Receptor. The Receptors. Cham: Springer International Publishing. pp. 169–200.doi:10.1007/978-3-031-67148-7_8.ISBN 978-3-031-67147-0. Retrieved28 January 2026.

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GABA receptor modulators

GABA_ATooltip γ-Aminobutyric acid A receptor

Positive modulators (abridged; seehere for a full list):α-EMTBL
Alcohols (e.g.,drinking alcohol,2M2B)
Anabolic steroids
Avermectins (e.g.,ivermectin)
Barbiturates (e.g.,phenobarbital)
Benzodiazepines (e.g.,diazepam)
Bromide compounds (e.g.,potassium bromide)
Carbamates (e.g.,meprobamate)
Carbamazepine
Chloralose
Chlormezanone
Clomethiazole
Dihydroergolines (e.g.,ergoloid (dihydroergotoxine))
Etazepine
Etifoxine
Fenamates (e.g.,mefenamic acid)
Flavonoids (e.g.,apigenin,hispidulin)
Fluoxetine
Flupirtine
Imidazoles (e.g.,etomidate)
Kava constituents (e.g.,kavain)
Lanthanum
Loreclezole
Monastrol
Neuroactive steroids (e.g.,allopregnanolone,cholesterol,THDOC)
Niacin
Niacinamide
Nonbenzodiazepines (e.g.,β-carbolines (e.g.,abecarnil),cyclopyrrolones (e.g.,zopiclone),imidazopyridines (e.g.,zolpidem),pyrazolopyrimidines (e.g.,zaleplon))
Norfluoxetine
Petrichloral
Phenols (e.g.,propofol)
Phenytoin
Piperidinediones (e.g.,glutethimide)
Propanidid
Pyrazolopyridines (e.g.,etazolate)
Quinazolinones (e.g.,methaqualone)
Retigabine (ezogabine)
ROD-188
Skullcap constituents (e.g.,baicalin)
Stiripentol
Sulfonylalkanes (e.g.,sulfonmethane (sulfonal))
Topiramate
Valerian constituents (e.g.,valerenic acid)
Volatiles/gases (e.g.,chloral hydrate,chloroform,diethyl ether,paraldehyde,sevoflurane)

GABA_A-ρTooltip γ-Aminobutyric acid A-rho receptor

Negative modulators:5α-Dihydroprogesterone
Bilobalide
Loreclezole
Picrotoxin (picrotin,picrotoxinin)
Pregnanolone
ROD-188
THDOC
Zinc

GABA_BTooltip γ-Aminobutyric acid B receptor

Negative modulators:Compound 14

See also: Receptor/signaling modulators; GABA_A receptor positive modulators; GABA metabolism/transport modulators

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