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IL18RAP

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
IL18RAP
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

3WO4

Identifiers
AliasesIL18RAP, ACPL, CD218b, CDw218b, IL-18R-beta, IL-18RAcP, IL-18Rbeta, IL-1R-7, IL-1R7, IL-1RAcPL, IL18RB, interleukin 18 receptor accessory protein
External IDsOMIM:604509;MGI:1338888;HomoloGene:2859;GeneCards:IL18RAP;OMA:IL18RAP - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for IL18RAP
Genomic location for IL18RAP
Band2q12.1Start102,418,689bp[1]
End102,452,565bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for IL18RAP
Genomic location for IL18RAP
Band1|1 BStart40,554,522bp[2]
End40,590,865bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • blood

  • bone marrow

  • spleen

  • trabecular bone

  • right lung

  • bone marrow cells

  • upper lobe of left lung

  • periodontal fiber

  • appendix
Top expressed in
  • granulocyte

  • blood

  • tibiofemoral joint

  • embryo

  • bone marrow

  • spleen

  • zygote

  • endothelial cell of lymphatic vessel

  • carotid body

  • subcutaneous adipose tissue
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8807

16174

Ensembl

ENSG00000115607

ENSMUSG00000026068

UniProt

O95256

Q9Z2B1

RefSeq (mRNA)

NM_003853

NM_010553

RefSeq (protein)

NP_003844

NP_034683

Location (UCSC)Chr 2: 102.42 – 102.45 MbChr 1: 40.55 – 40.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 18 receptor accessory protein, also known asIL18RAP andCDw218b (cluster of differentiation w218b), is a humangene.[5][6]

Function

[edit]

Theprotein encoded by this gene is an accessory subunit of the heterodimericreceptor forIL18. This protein enhances the IL18 binding activity ofIL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation ofNF-κB andMAPK8 (JNK) in response to IL18.[5]

Disease association

[edit]

Variants at IL18RAP have been linked to susceptibility toCoeliac disease.[7]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000115607Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000026068Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ab"Entrez Gene: IL18RAP interleukin 18 receptor accessory protein".
  6. ^Born TL, Thomassen E, Bird TA, Sims JE (November 1998)."Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling".J. Biol. Chem.273 (45):29445–50.doi:10.1074/jbc.273.45.29445.PMID 9792649.
  7. ^Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C, van Heel DA (April 2008)."Novel celiac disease genetic determinants related to the immune response".Nat. Genet.40 (4):395–402.doi:10.1038/ng.102.PMC 2673512.PMID 18311140.

Further reading

[edit]

External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

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