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IL18R1

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

IL18R1

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
3WO3,3WO4,4R6U

Identifiers

Aliases

IL18R1, CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP, interleukin 18 receptor 1, IL-18R-alpha, IL18Ralpha2, IL-18Ralpha

External IDs

OMIM:604494;MGI:105383;HomoloGene:2861;GeneCards:IL18R1;OMA:IL18R1 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q12.1	Start	102,311,529bp^[1]
Band	2q12.1	End	102,398,777bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 B	Start	40,504,712bp^[2]
Band	1\|1 B	End	40,540,014bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right lung

upper lobe of left lung

testicle

blood

granulocyte

spleen

appendix

gallbladder

right lobe of liver

left uterine tube

Top expressed in

right lung lobe

left lung

conjunctival fornix

granulocyte

left lung lobe

blood

transitional epithelium of urinary bladder

mesenteric lymph nodes

spleen

pharynx

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	interleukin-18 receptor activity protein binding interleukin-1 receptor activity signaling receptor activity interleukin-18 binding
Cellular component	integral component of membrane plasma membrane membrane interleukin-18 receptor complex
Biological process	natural killer cell activation positive regulation of interferon-gamma production T-helper 1 cell differentiation immune response signal transduction interleukin-18-mediated signaling pathway cellular response to cytokine stimulus positive regulation of NIK/NF-kappaB signaling positive regulation of NF-kappaB transcription factor activity positive regulation of T-helper 1 cell cytokine production inflammatory response negative regulation of cold-induced thermogenesis
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


8809


16182

Ensembl


ENSG00000115604


ENSMUSG00000026070

UniProt


Q13478


Q61098

RefSeq (mRNA)

NM_001282399 NM_003855 NM_001371418 NM_001371419 NM_001371420
NM_001371421 NM_001371422 NM_001371423 NM_001371424


NM_001161842 NM_001161843 NM_008365

RefSeq (protein)

NP_001269328 NP_003846 NP_001358347 NP_001358348 NP_001358349
NP_001358350 NP_001358351 NP_001358352 NP_001358353


NP_001155314 NP_001155315 NP_032391

Location (UCSC)

Chr 2: 102.31 – 102.4 Mb

Chr 1: 40.5 – 40.54 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Theinterleukin-18 receptor 1 (IL-18R1) is aninterleukin receptor of theimmunoglobulin superfamily.IL18R1 is its humangene.^[5] IL18R1 is also known asCDw218a (cluster of differentiation w218a).

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000115604 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000026070 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^b"Entrez Gene: IL18R1 interleukin 18 receptor 1".

External links

[edit]

IL18R1+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

v t e Proteins:clusters of differentiation (see alsolist of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 -CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 -CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Transmembrane receptors:immunoglobulin superfamily immune receptors

Antibody receptor:
Fc receptor

Epsilon (ε)	FcεRI (FcεRII isC-type lectin)
Gamma (γ)	FcγRI FcγRII FcγRIII Neonatal
Alpha (α)/mu (μ)	FcαRI Fcα/μR
Secretory	Polymeric immunoglobulin receptor

Antigen receptor

B cells

Antigen receptor

Co-receptor

stimulate:	CD21/CD19/CD81
inhibit:	CD22

Accessory molecules

Ig-α/Ig-β (CD79)

T cells

Ligands	MHC MHC class I MHC class II
Antigen receptor	TCR:TRA@ TRB@ TRD@ TRG@
Co-receptors	CD8 (with two glycoprotein chainsCD8α andCD8β) CD4
Accessory molecules	CD3 CD3γ CD3δ CD3ε ζ-chain (also calledCD3ζ andTCRζ)

Cytokine receptor

seecytokine receptors

Killer-cell IG-like receptors

Leukocyte IG-like receptors

Cytokine receptors

Chemokine receptor
(GPCRs)

CC	CCR1 /CCRL1 CCR2 CCRL2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCR10
CXC	IL-8 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXCR7
Other	CX3C CX3CR1 XC XCR1 CCBP2 CMKLR1

TNF receptor

1-10	TNFR1(TNFRSF1A) TNFR2(TNFRSF1B) LTBR(TNFRSF3) CD134(TNFRSF4) CD40(TNFRSF5) Fas receptor(TNFRSF6) DcR3(TNFRSF6B) CD27(TNFRSF7) CD30(TNFRSF8) CD137(TNFRSF9)
11-20	DR4(TNFRSF10A) DR5(TNFRSF10B) DcR1(TNFRSF10C) DcR2(TNFRSF10D) RANK(TNFRSF11A) Osteoprotegerin(TNFRSF11B) TweakR(TNFRSF12A) TACI(TNFRSF13B) BAFFR(TNFRSF13C) HVEM(TNFRSF14) NGFR(TNFRSF16) BCMA(TNFRSF17) GITR(TNFRSF18) TAJ/TROY(TNFRSF19)
21-27	DR6(TNFRSF21) DR3(TNFRSF25) EDA2R(TNFRSF27)

JAK-STAT

Type I

γ-chain	Interleukin receptors IL2R /IL2RA/IL2RB /IL15R IL4R /IL13R /IL13RA1 /IL13RA2 IL7R /IL7RA IL9R IL21R
β-chain	Interleukin receptors IL3R /IL3RA IL5R /IL5RA GM-CSF
gp130	Interleukin receptors IL6RA 11/IL11RA 27/IL27RA OSMR LIFR CNTFR
IL12RB1	Interleukin receptors IL12R/IL12RB1/IL12RB2 IL23R
Other	otherCSF receptors EPO G-CSF Thrombopoietin hormone receptor:GH prolactin

Type II

Interleukin receptors
- IL10R /IL10RA /IL10RB /IL22R /IL22RA1 /IL22RA2
- IL20R /IL20RA /IL20RB
- IL28R
Interferon receptors
- -α/β /IFNAR1/IFNAR2
- -γ/IFNGR1 /IFNGR2

Ig superfamily

IL1
- IL1R1
- IL1R2
IL18R /IL18R1

IL 17 family

IL17

Enzyme-linked receptor

Interleukin receptor modulators

IL-1

Decoy receptors:Rilonacept (IL-1 Trap)

IL-2

IL-3

IL-4

Antagonists:Pitrakinra

Antibodies:Dupilumab
Pascolizumab

IL-5

Agonists:Interleukin 5

Antagonists:YM-90709

Antisense oligonucleotides:TPI ASM8

IL-6

Agonists:Atexakin alfa
Interleukin 6

IL-7

Agonists:Interleukin 7

IL-8

See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)here instead.

IL-9

Agonists:Interleukin 9

Antibodies:Enokizumab

IL-10

Agonists:Ilodecakin
Interleukin 10 (CSIF)

IL-11

Agonists:Interleukin 11 (AGIF)
Oprelvekin

IL-12

Agonists:Edodekin alfa
Interleukin 12

Antibodies:Briakinumab
Ustekinumab

IL-13

IL-15

Agonists:ALT-803
Interleukin 15

IL-17

Agonists:Interleukin 17 (A,B,C,D,E (interleukin 25),F)

IL-18

Binding proteins:IL18BP

IL-20

Antibodies:Fletikumab (against IL-20)

IL-21

Agonists:Denenicokin
Interleukin 21

Antibodies:NNC0114-0005
NNC0114-0006

IL-22

Agonists:Interleukin 22

Antibodies:Fezakinumab (against IL-22)

IL-23

Agonists:Interleukin 23 (SGRF)

IL-27

Agonists:Interleukin 27 (interleukin 30)

IL-28

IL-31

Agonists:Interleukin 31

IL1RL1

Agonists:Interleukin 33

IL1RL2

Agonists:Interleukin 36 (α,β,γ)
Interleukin 38

Antagonists:IL-36RA

Others

JAK	Seehere instead.
Others	Interleukin 14 (taxilin alpha, HMW-BCGF) Interleukin 16 (signals throughCD4) Interleukin 24 (signals throughIL-22Rα1/IL-20Rβ heterodimer) Interleukin 26 (signals throughIL-20Rα/IL-10Rβ heterodimer) Interleukin 32 Interleukin 34 (signals throughM-CSFR/CSF1R) Interleukin 35 Unsorted:Efavaleukin alfa Efineptakin alfa