Protein-coding gene in the species Homo sapiens
Interleukin 13 receptor, alpha 1 , also known asIL13RA1 andCD213A1 (cluster of differentiation 213A1), is a humangene .[ 5]
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primaryIL13 -binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.[ 5]
IL13RA1 expression has been linked to higher survival rates forlung cancer patients.[ 6]
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