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IFNA14

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

IFNA14

Identifiers

Aliases

IFNA14, IFN-alphaH, LEIF2H, interferon alpha 14

External IDs

OMIM:147579;MGI:2667155;HomoloGene:122139;GeneCards:IFNA14;OMA:IFNA14 - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9p21.3	Start	21,239,002bp^[1]
Band	9p21.3	End	21,240,005bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4 C4\|4 42.02 cM	Start	88,561,878bp^[2]
Band	4 C4\|4 42.02 cM	End	88,562,696bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

renal cortex

muscle of leg

kidney

gastrocnemius muscle

multicellular organism

Top expressed in

embryo

embryo

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	cytokine activity type I interferon receptor binding cytokine receptor binding
Cellular component	extracellular region extracellular space
Biological process	natural killer cell activation involved in immune response B cell differentiation defense response B cell proliferation blood coagulation positive regulation of peptidyl-serine phosphorylation of STAT protein humoral immune response adaptive immune response defense response to virus type I interferon signaling pathway response to exogenous dsRNA T cell activation involved in immune response innate immune response cytokine-mediated signaling pathway regulation of signaling receptor activity
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


3448


230396

Ensembl


ENSG00000228083


ENSMUSG00000063376

UniProt


P01570


Q80SU4

RefSeq (mRNA)


NM_002172


NM_177347

RefSeq (protein)


NP_002163


NP_796321

Location (UCSC)

Chr 9: 21.24 – 21.24 Mb

Chr 4: 88.56 – 88.56 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Interferon alpha-14 is aprotein that in humans is encoded by theIFNA14gene.^[5]^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000228083 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000063376 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia".Genomics.14 (2):437–43.doi:10.1016/S0888-7543(05)80238-1.PMID 1385305.
^"Entrez Gene: IFNA14 interferon, alpha 14".

Sen GC, Lengyel P (1992)."The interferon system. A bird's eye view of its biochemistry".J. Biol. Chem.267 (8):5017–20.doi:10.1016/S0021-9258(18)42719-6.PMID 1371992.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin".J. Infect.24 (3):317–20.doi:10.1016/S0163-4453(05)80037-4.PMID 1602151.
Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes".J. Mol. Biol.185 (2):227–60.doi:10.1016/0022-2836(85)90401-2.PMID 4057246.
Goeddel DV, Leung DW, Dull TJ, et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs".Nature.290 (5801):20–6.Bibcode:1981Natur.290...20G.doi:10.1038/290020a0.PMID 6163083.S2CID 1900300.
Lawn RM, Adelman J, Dull TJ, et al. (1981). "DNA sequence of two closely linked human leukocyte interferon genes".Science.212 (4499):1159–62.Bibcode:1981Sci...212.1159L.doi:10.1126/science.6165082.PMID 6165082.
Tiefenbrun N, Melamed D, Levy N, et al. (1996)."Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest".Mol. Cell. Biol.16 (7):3934–44.doi:10.1128/MCB.16.7.3934.PMC 231390.PMID 8668211.
Hussain M, Gill DS, Liao MJ (1997). "Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population".J. Interferon Cytokine Res.16 (10):853–9.doi:10.1089/jir.1996.16.853.PMID 8910771.
Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998)."Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes".Biochem. J.329 (Pt 2):295–302.doi:10.1042/bj3290295.PMC 1219044.PMID 9425112.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.

Cytokine receptor modulators

Chemokine

Seehere instead.

CSF

Erythropoietin	Agonists:ARA-290 Asialo erythropoietin Carbamylated erythropoietin CNTO-530 Darbepoetin alfa Epoetin alfa Epoetin beta Epoetin delta Epoetin epsilon Epoetin gamma Epoetin kappa Epoetin omega Epoetin theta Epoetin zeta Erythropoietin (EPO) Erythropoietin-Fc Methoxy polyethylene glycol-epoetin beta (CERA/Mircera) Peginesatide Pegol sihematide (EPO-018B)
G-CSF (CSF3)	Agonists:Filgrastim Granulocyte colony-stimulating factor Lenograstim Leridistim Lipegfilgrastim Nartograstim Pegfilgrastim Pegnartograstim
GM-CSF (CSF2)	Agonists:Ecogramostim Granulocyte macrophage colony-stimulating factor Milodistim Molgramostim Regramostim Sargramostim Antibodies:Mavrilimumab Namilumab Otilimab
M-CSF (CSF1)	Agonists:Cilmostim Interleukin-34 Lanimostim Macrophage colony-stimulating factor Mirimostim Kinase inhibitors:Agerafenib
SCF (c-Kit)	Seehere instead.
Thrombopoietin	Agonists:Eltrombopag Pegacaristim Promegapoietin Romiplostim Thrombopoietin (THPO, MGDF)

Interferon

IFNAR (α/β, I)	Agonists:Albinterferon Interferon alpha (interferon alfa, IFN-α) Interferon alfa (IFNA1,IFNA2,IFNA4,IFNA5,IFNA6,IFNA7,IFNA8,IFNA10,IFNA13,IFNA14,IFNA16,IFNA17,IFNA21) Interferon alfa 2a Interferon alfa 2b Interferon alfa n1 Interferon alfacon-1 Interferon alpha-n3 Interferon beta (IFN-β) (IFNB1,IFNB3) Interferon beta 1a Interferon beta 1b Interferon kappa (IFN-ε/κ/τ/ζ, IFNK) Interferon omega (IFN-ω, IFNW1) Peginterferon alfa-2a Peginterferon alfa-2b Antibodies:Anifrolumab Faralimomab MEDI-545 Rontalizumab Sifalimumab Decoy receptors:Bifarcept
IFNGR (γ, II)	Agonists:Interferon gamma (IFN-γ) Interferon gamma 1b Antibodies:Emapalumab Fontolizumab
IFNLR (λ, III)	See IL-28R (IFNLR)here instead.

Interleukin

Seehere instead.

TGFβ

Seehere instead.

TNF

Seehere instead.

Others

JAK
(inhibitors)

JAK1	Abrocitinib Baricitinib Deuruxolitinib Filgotinib Momelotinib Oclacitinib Peficitinib Ruxolitinib Tofacitinib (tasocitinib) Upadacitinib
JAK2	Atiprimod AZD-1480 Baricitinib CHZ868 Cucurbitacin I (elatericin B, JSI-124) CYT387 Deuruxolitinib Lestaurtinib NSC-7908 NSC-33994 Pacritinib Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib)
JAK3	Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib) WHI-P 154 ZM-39923 ZM-449829
TYK2	Deucravacitinib

Others

Additional cytokine receptor modulators:Emfilermin
Lestaurtinib
Midostaurin
Quizartinib
Sorafenib
Sunitinib

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