The protein encoded by this gene belongs to the inhibitor of DNA binding (ID) family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene has been identified for this gene.[6]The ID2 protein may play a role in the development and resistance to therapies ofglioblastoma, the most aggressive of brain cancers.[7]
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Kurabayashi M, Jeyaseelan R, Kedes L (November 1993). "Two distinct cDNA sequences encoding the human helix-loop-helix protein Id2".Gene.133 (2):305–306.doi:10.1016/0378-1119(93)90658-P.PMID8224921.
Mathew S, Chen W, Murty VV, Benezra R, Chaganti RS (November 1995). "Chromosomal assignment of human ID1 and ID2 genes".Genomics.30 (2):385–387.doi:10.1006/geno.1995.0037.PMID8586447.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200 (1–2):149–156.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
Yokota Y, Mansouri A, Mori S, Sugawara S, Adachi S, Nishikawa S, et al. (February 1999). "Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2".Nature.397 (6721):702–706.Bibcode:1999Natur.397..702Y.doi:10.1038/17812.PMID10067894.S2CID4428856.
Law SF, Zhang YZ, Fashena SJ, Toby G, Estojak J, Golemis EA (October 1999). "Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain".Experimental Cell Research.252 (1):224–235.doi:10.1006/excr.1999.4609.PMID10502414.
Liu J, Shi W, Warburton D (July 2000). "A cysteine residue in the helix-loop-helix domain of Id2 is critical for homodimerization and function".Biochemical and Biophysical Research Communications.273 (3):1042–1047.doi:10.1006/bbrc.2000.3055.PMID10891368.
Wong J, Funes-Duran M, Ahlberg J, Round J, O'Connell R, Miller R, et al. (August 2001). "Characterization of a basic helix-loop-helix protein, ABF-1: nuclear localization, transcriptional properties, and interaction with Id-2".DNA and Cell Biology.20 (8):465–471.doi:10.1089/104454901316976091.PMID11560778.
