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| Clinical data | |
|---|---|
| Trade names | Cortavance, others |
| AHFS/Drugs.com | Monograph |
| Routes of administration | Topical |
| Drug class | Corticosteroid |
| ATC code | |
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| Legal status | |
| Pharmacokinetic data | |
| Metabolism | Liver |
| Eliminationhalf-life | 6-8 hours |
| Identifiers | |
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| CAS Number | |
| PubChemCID | |
| DrugBank |
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| ChemSpider |
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| UNII | |
| KEGG |
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| ChEBI | |
| ChEMBL | |
| ECHA InfoCard | 100.184.885 |
| Chemical and physical data | |
| Formula | C26H36O7 |
| Molar mass | 460.567 g·mol−1 |
| 3D model (JSmol) | |
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Hydrocortisone aceponate is a veterinarycorticosteroid that is used in form ofcreams for the treatment of variousdermatoses (skin conditions).[6] It is anester ofhydrocortisone (cortisol) withacetic acid andpropionic acid.
Hydrocortisone aceponate is typically used for skin conditions in veterinary practices for dogs. In this instance, it can be used on acuteotitis externa,[7] a bacterial infection causing inflammation of the ear canal, as well as a treatment for itchy skin caused by allergies.[1] Additionally, hydrocortisone aceponate can be used to treat hormonal disorders and immune and allergic disorders.[8][unreliable medical source?] The main use for hydrocortisone aceponate is for atopic skin conditions and acute ear infections. It is shown to help with skin lesions andinflammation that respond to corticosteroids but may have been resistant to other treatments. It has been approved for veterinary use in theEuropean Union.[7][1][2][4]
Side effects include:[1]
Hydrocortisone aceponate is a steroid which takes the form of a diester. The diester increases transmission of the medicine[1] through the skin and also increases the time that it remains in the affected area.[9]
Cortavance is the brand name for a veterinary medication used to treat inflamed, itchy skin, typically caused by allergies.[1]
Easotic is the brand name for a veterinary combination medication used to treat acute ear infections in dogs.[7] It is composed of three active substances: hydrocortisone aceponate, miconazole nitrate and gentamicin. These are used in conjunction with hydrocortisone aceponate acts as an anti-inflammatory agent, miconazole nitrate has antifungal properties, and gentamicin is an antibiotic. The medication is used through ear drops and works to kill the foreign agent, prevent further spread, and mitigate symptoms.[7]
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