Ahybrid mass spectrometer is a device fortandem mass spectrometry that consists of a combination of two or morem/z separation devices of different types.
Asector instrument can be combined with a collision quadrupole andquadrupole mass analyzer to form a hybrid instrument.[1] A BEqQ configuration with a magnetic sector (B), electric sector (E), collision quadrupole (q) andm/z selection quadrupole (Q) have been constructed[2][3] and an instrument with two electric sectors (BEEQ) has been described.[4]
Hybrid quadrupole time-of-flight mass spectrometer.
Atriple quadrupole mass spectrometer with the final quadrupole replaced by a time-of-flight device is known as a quadrupole time-of-flight instrument.[5][6] Such an instrument can be represented as QqTOF.
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^Schoen, A.; Amy, J.W.; Ciupek, J.D.; Cooks, R.G.; Dobberstein, P.; Jung, G. (1985). "A hybrid BEQQ mass spectrometer".International Journal of Mass Spectrometry and Ion Processes.65 (1–2):125–140.Bibcode:1985IJMSI..65..125S.doi:10.1016/0168-1176(85)85059-X.
^Winger, B. E.; Laue, H. -J.; Horning, S. R.; Julian, R. K.; Lammert, S. A.; Riederer, D. E.; Cooks, R. G. (1992). "Hybrid BEEQ tandem mass spectrometer for the study of ion/surface collision processes".Review of Scientific Instruments.63 (12): 5613.Bibcode:1992RScI...63.5613W.doi:10.1063/1.1143391.
^Shevchenko A, Loboda A, Shevchenko A, Ens W, Standing KG (May 2000). "MALDI quadrupole time-of-flight mass spectrometry: a powerful tool for proteomic research".Anal. Chem.72 (9):2132–41.doi:10.1021/ac9913659.PMID10815976.
^Steen H, Küster B, Mann M (July 2001). "Quadrupole time-of-flight versus triple-quadrupole mass spectrometry for the determination of phosphopeptides by precursor ion scanning".J Mass Spectrom.36 (7):782–90.Bibcode:2001JMSp...36..782S.doi:10.1002/jms.174.PMID11473401.
^Fountain ST, Lee H, Lubman DM (May 1994). "Ion fragmentation activated by matrix-assisted laser desorption/ionization in an ion-trap/reflectron time-of-flight device".Rapid Commun. Mass Spectrom.8 (5):407–16.Bibcode:1994RCMS....8..407F.doi:10.1002/rcm.1290080514.PMID7517726.
^Syka JE, Marto JA, Bai DL, et al. (2004). "Novel linear quadrupole ion trap/FT mass spectrometer: performance characterization and use in the comparative analysis of histone H3 post-translational modifications".J. Proteome Res.3 (3):621–6.doi:10.1021/pr0499794.PMID15253445.
^Makarov A, Denisov E, Kholomeev A, Balschun W, Lange O, Strupat K, Horning S (2006). "Performance evaluation of a hybrid linear ion trap/orbitrap mass spectrometer".Anal. Chem.78 (7):2113–20.doi:10.1021/ac0518811.PMID16579588.
^Yates JR, Cociorva D, Liao L, Zabrouskov V (January 2006). "Performance of a linear ion trap-Orbitrap hybrid for peptide analysis".Anal. Chem.78 (2):493–500.doi:10.1021/ac0514624.PMID16408932.
