A homologous booster shot involves the administration of thesame vaccine as previously administered, while a heterologous booster shot involves the administration of adifferent vaccine.[1]
"Heterologous prime-boost immunization is administration of twodifferent vectors or delivery systems expressing the same or overlapping antigenic inserts."[2]
"An effective vaccine usually requires more than one time immunization in the form of prime-boost. Traditionally the same vaccines are given multiple times as homologous boosts. New findings suggested that prime-boost can be done withdifferent types of vaccines containing the same antigens. In many cases such heterologous prime-boost can be more immunogenic than homologous prime-boost."[3]
The authors concluded that the SARS-CoV-2 anti-spike IgG concentrations of both heterologous schedules were higher than that of a licensed vaccine schedule (ChAd/ChAd) with proven efficacy against coronavirus disease 2019 (COVID-19) disease and hospitalization
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