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Hepatoma-derived growth factor

From Wikipedia, the free encyclopedia
Protein capable of worsening malignant diseases
HDGF
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1RI0,2NLU

Identifiers
AliasesHDGF, HMG1L2, hepatoma-derived growth factor, heparin binding growth factor
External IDsOMIM:600339;MGI:1194494;HomoloGene:3306;GeneCards:HDGF;OMA:HDGF - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for HDGF
Genomic location for HDGF
Band1q23.1Start156,742,109bp[1]
End156,766,925bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for HDGF
Genomic location for HDGF
Band3 F1|3 38.78 cMStart87,813,628bp[2]
End87,823,439bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • ganglionic eminence

  • mucosa of ileum

  • olfactory zone of nasal mucosa

  • mucosa of transverse colon

  • right uterine tube

  • rectum

  • skin of leg

  • gastrocnemius muscle

  • skin of abdomen
Top expressed in
  • otic placode

  • otic vesicle

  • saccule

  • Ileal epithelium

  • fetal liver hematopoietic progenitor cell

  • epiblast

  • lactiferous gland

  • ventricular zone

  • lip

  • yolk sac
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3068

15191

Ensembl

ENSG00000143321

ENSMUSG00000004897

UniProt

P51858

P51859

RefSeq (mRNA)
NM_001126050
NM_001126051
NM_004494
NM_001319186
NM_001319187

NM_001319188

NM_008231
NM_001331051
NM_001331052

RefSeq (protein)
NP_001119522
NP_001119523
NP_001306115
NP_001306116
NP_001306117

NP_004485

NP_001317980
NP_001317981
NP_032257

Location (UCSC)Chr 1: 156.74 – 156.77 MbChr 3: 87.81 – 87.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hepatoma-derived growth factor (HDGF) also known ashigh mobility group protein 1-like 2 (HMG-1L2) is aprotein that in humans is encoded by theHDGFgene.[5][6]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000143321Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000004897Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Wanschura S, Schoenmakers EF, Huysmans C, Bartnitzke S, Van de Ven WJ, Bullerdiek J (May 1997). "Mapping of the gene encoding the human hepatoma-derived growth factor (HDGF) with homology to the high-mobility group (HMG)-1 protein to Xq25".Genomics.32 (2):298–300.doi:10.1006/geno.1996.0122.PMID 8833162.
  6. ^"Entrez Gene: HDGF hepatoma-derived growth factor (high-mobility group protein 1-like)".

Further reading

[edit]

External links

[edit]
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Hepatoma-derived growth factor
PDB gallery
  • 1ri0: NMR structure of the N-terminal hath domain of human HDGF
    1ri0: NMR structure of the N-terminal hath domain of human HDGF
  • 2b8a: High Resolution Structure of the HDGF PWWP Domain
    2b8a: High Resolution Structure of the HDGF PWWP Domain
Angiopoietin
CNTF
EGF (ErbB)
EGF
(ErbB1/HER1)
ErbB2/HER2
ErbB3/HER3
ErbB4/HER4
FGF
FGFR1
FGFR2
FGFR3
FGFR4
Unsorted
HGF (c-Met)
IGF
IGF-1
IGF-2
Others
LNGF (p75NTR)
PDGF
RET (GFL)
GFRα1
GFRα2
GFRα3
GFRα4
Unsorted
SCF (c-Kit)
TGFβ
Trk
TrkA
TrkB
TrkC
VEGF
Others


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