Hepatocyte nuclear factor 4 gamma (HNF4G) also known asNR2A2 (nuclear receptor subfamily 2, group A, member 2) is anuclear receptor that in humans is encoded by theHNF4Ggene.[5][6][7]
HNF4G is a transcription factor that has been shown to play a significant role in intestinal epithelial cell differentiation and function. Research using integrative multi-omics analysis of intestinal organoid differentiation has revealed that HNF4G acts as a master regulator of gene regulation in differentiation towards the enterocyte lineage.[8] The study demonstrated widespread binding to promoters and enhancers that are activated in enterocytes, and that the loss of Hnf4g results in a partial loss of enterocyte differentiation, indicating its importance in maintaining the enterocyte lineage.
Plengvidhya N, Antonellis A, Wogan LT, Poleev A, Borgschulze M, Warram JH, et al. (October 1999). "Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes".Diabetes.48 (10):2099–2102.doi:10.2337/diabetes.48.10.2099.PMID10512380.
Ozeki T, Takahashi Y, Nakayama K, Funayama M, Nagashima K, Kodama T, et al. (January 2003). "Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers".Pharmacogenetics.13 (1):49–53.doi:10.1097/00008571-200301000-00007.PMID12544512.
