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Chemical structures of ethyl linoleate — natural (top) and its deuterated version11,11-D2-ethyl linoleate.Protium hydrogen atoms (H) are explicitly shown where they are replaced withdeuterium atoms (D).
Heavy isotope diet is the consumption ofnutrients in which some atoms are replaced with their heavier non-radioactiveisotopes, such asdeuterium (2H) orheavy carbon (13C). Biomolecules that incorporate heavier isotopes give rise to more stable molecular structures under certain circumstances, which is hypothesized to increase resistance to damage associated withageing[1] or diseases.[2][3]
One of the most pernicious and irreparable types ofoxidative damage inflicted byreactive oxygen species (ROS) upon biomolecules involves the carbon-hydrogen bond cleavage (hydrogen abstraction). Intriguingly, the biomolecules most damageable by this type of damage belong to the group ofessential nutrients (10 out of 20 amino acids; nucleosides at certain conditions (conditionally essential); allpolyunsaturated fatty acids). In theory, replacing hydrogen with deuterium "reinforces" the bond due to thekinetic isotope effect, and such reinforced biomolecules taken up by the body will be more resistant to ROS.[7]
Deuterated omega-6 fatty acids for humans with degenerative diseases
^Korneenko, Tatyana V; Pestov, Nikolay B; Hurski, Alaksiej L; Fedarkevich, Artsiom M; Shmanai, Vadim V; Brenna, J. Thomas; Shchepinov, Mikhail S (2017). "A strong developmental isotope effect in Caenorhabditis elegans induced by 5,5-deuterated lysine".Amino Acids.49 (5):887–894.doi:10.1007/s00726-017-2386-5.PMID28161800.S2CID625937.
^Woodcock, Clayton B; Ulashchik, Egor A; Poopeiko, Nikolai E; Shmanai, Vadim V; Reich, Norbert O; Shchepinov, Mikhail S (2016). "Rational Manipulation of DNA Methylation by Using Isotopically Reinforced Cytosine".ChemBioChem.17 (21):2018–2021.doi:10.1002/cbic.201600393.PMID27595234.S2CID19507501.
