Protein-coding gene in the species Homo sapiens
Heat shock factor protein 2 is aprotein that in humans is encoded by theHSF2 gene .[ 5] [ 6]
HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Although the names HSF1 and HSF2 were chosen for historical reasons, these peptides should be referred to as heat-shock transcription factors.[ 6]
HSF2 has been shown tointeract withNucleoporin 62 [ 7] HSF1 .[ 8]
^a b c GRCh38: Ensembl release 89: ENSG00000025156 –Ensembl , May 2017^a b c GRCm38: Ensembl release 89: ENSMUSG00000019878 –Ensembl , May 2017^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ Schuetz TJ, Gallo GJ, Sheldon L, Tempst P, Kingston RE (Sep 1991)."Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans" .Proc Natl Acad Sci U S A .88 (16):6911– 5.Bibcode :1991PNAS...88.6911S .doi :10.1073/pnas.88.16.6911 PMC 52203 PMID 1871106 . ^a b "Entrez Gene: HSF2 heat shock transcription factor 2" .^ Yoshima T, Yura T, Yanagi H (Nov 1997). "The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62".Biochem. Biophys. Res. Commun .240 (1):228– 33.Bibcode :1997BBRC..240..228Y .doi :10.1006/bbrc.1997.7662 .PMID 9367915 . ^ He H, Soncin F, Grammatikakis N, Li Y, Siganou A, Gong J, Brown SA, Kingston RE, Calderwood SK (Sep 2003)."Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress" .J. Biol. Chem .278 (37):35465– 75.doi :10.1074/jbc.M304663200 PMID 12813038 . Walsh D, Li Z, Wu Y, Nagata K (1997)."Heat shock and the role of the HSPs during neural plate induction in early mammalian CNS and brain development" .Cell. Mol. Life Sci .53 (2):198– 211.doi :10.1007/PL00000592 .PMC 11147247 PMID 9118008 .S2CID 32425345 . Sarge KD, Zimarino V, Holm K, Wu C, Morimoto RI (1991)."Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability" .Genes Dev .5 (10):1902– 11.doi :10.1101/gad.5.10.1902 PMID 1717345 . Maruyama K, Sugano S (1994). 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Roccisana JL, Kawanabe N, Kajiya H, Koide M, Roodman GD, Reddy SV (2004)."Functional role for heat shock factors in the transcriptional regulation of human RANK ligand gene expression in stromal/osteoblast cells" .J. Biol. Chem .279 (11):10500– 7.doi :10.1074/jbc.M303727200 PMID 14699143 . Xing H, Wilkerson DC, Mayhew CN, Lubert EJ, Skaggs HS, Goodson ML, Hong Y, Park-Sarge OK, Sarge KD (2005). "Mechanism of hsp70i gene bookmarking".Science .307 (5708):421– 3.Bibcode :2005Sci...307..421X .doi :10.1126/science.1106478 .PMID 15662014 .S2CID 37132180 . Anckar J, Hietakangas V, Denessiouk K, Thiele DJ, Johnson MS, Sistonen L (2006)."Inhibition of DNA binding by differential sumoylation of heat shock factors" .Mol. Cell. Biol .26 (3):955– 64.doi :10.1128/MCB.26.3.955-964.2006 .PMC 1347039 PMID 16428449 . This article incorporates text from theUnited States National Library of Medicine , which is in thepublic domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4)β-Scaffold factors with minor groove contacts
(0) Other transcription factors
