This gene is a member of theAntp homeobox family and encodes anuclear protein with ahomeoboxDNA-binding domain. It is included in acluster of homeobox B genes located onchromosome 17. The encoded protein functions as a sequence-specifictranscription factor that is involved in development. Intracellular or ectopicexpression of this protein expandshematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.[7]
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Theokli C, Morsi El-Kadi AS, Morgan R (May 2003). "TALE class homeodomain gene Irx5 is an immediate downstream target for Hoxb4 transcriptional regulation".Developmental Dynamics.227 (1):48–55.doi:10.1002/dvdy.10287.PMID12701098.S2CID10293029.
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