HOT-x, also known as4-alkylthio-2,5-dimethoxy-N-hydroxyphenethylamines orhydroxylated 2C-T derivatives, are a group ofpsychedelic drugs of thephenethylamine and2C families.[1][2] They have ahydroxy group (HO) at theamine as well asmethoxy groups at the 2 and 5 positions and analkylthio (T) group at the 4 position of thephenyl ring.[1][2] The HOT-x drugs are theN-hydroxylanalogues of the corresponding2C-T-x drugs.[1][2]
The HOT-x drugs weresynthesized and tested byAlexander Shulgin and were reported by him in his 1991 bookPiHKAL (Phenethylamines I Have Known and Loved).[1][2]
| Compound | Chemical name | Dose | Duration | |
|---|---|---|---|---|
| HOT-2 (N-hydroxy-2C-T-2) | N-Hydroxy-4-ethylthio-2,5-dimethoxyphenethylamine | 10–18 mg | 6–10 hours | |
| HOT-7 (N-hydroxy-2C-T-7) | N-Hydroxy-4-propylthio-2,5-dimethoxyphenethylamine | 15–25 mg | 6–8 hours | |
| HOT-17 (N-hydroxy-2C-T-17) | N-Hydroxy-4-sec-butylthio-2,5-dimethoxyphenethylamine | 70–120 mg | 12–18 hours | |
| Refs:[2][3][4] | ||||
All three of the HOT-x drugs producepsychedelic effects according to Shulgin.[1][2] The HOT-x drugs are said to be very similar to their 2C-T counterparts in terms of properties and effects and may act asprodrugs to these compounds.[2]
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| Stimulants |
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| Depressants |
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| Hallucinogens |
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| Entactogens |
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| Psychiatric drugs |
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| Others |
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