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HMGN1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
HMGN1
Identifiers
AliasesHMGN1, HMG14, high mobility group nucleosome binding domain 1
External IDsOMIM:163920;MGI:96120;HomoloGene:3643;GeneCards:HMGN1;OMA:HMGN1 - orthologs
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for HMGN1
Genomic location for HMGN1
Band21q22.2Start39,342,315bp[1]
End39,349,647bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for HMGN1
Genomic location for HMGN1
Band16 C4|16 56.83 cMStart95,921,818bp[2]
End95,928,929bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • ganglionic eminence

  • endometrium

  • right uterine tube

  • appendix

  • lymph node

  • olfactory zone of nasal mucosa

  • rectum

  • islet of Langerhans

  • bone marrow
Top expressed in
  • neural layer of retina

  • yolk sac

  • ventricular zone

  • embryo

  • embryo

  • genital tubercle

  • tail of embryo

  • lip

  • zygote

  • right kidney
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3150

15312

Ensembl

ENSG00000205581

ENSMUSG00000040681

UniProt

P05114

P18608

RefSeq (mRNA)

NM_004965

NM_008251

RefSeq (protein)

NP_004956

NP_032277

Location (UCSC)Chr 21: 39.34 – 39.35 MbChr 16: 95.92 – 95.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Non-histone chromosomal protein HMG-14 is aprotein that in humans is encoded by theHMGN1gene.[5][6][7]

Function

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Chromosomal protein HMG14 and its close analogHMG17 (MIM 163910) bind to the inner side of thenucleosomal DNA, potentially altering the interaction between the DNA and thehistone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a uniquechromatin conformation.[8] Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.[7]

Interactions

[edit]

HMGN1 has been shown tointeract withYWHAZ.[9]

See also

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References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000205581Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000040681Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Landsman D, Srikantha T, Westermann R, Bustin M (Dec 1986)."Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family".The Journal of Biological Chemistry.261 (34):16082–6.doi:10.1016/S0021-9258(18)66680-3.PMID 3782107.
  6. ^Landsman D, McBride OW, Soares N, Crippa MP, Srikantha T, Bustin M (Feb 1989)."Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family".The Journal of Biological Chemistry.264 (6):3421–7.doi:10.1016/S0021-9258(18)94084-6.PMID 2563381.
  7. ^ab"Entrez Gene: HMGN1 high-mobility group nucleosome binding domain 1".
  8. ^Martínez de Paz A, Ausió J (2016)."HMGNs: The enhancer charmers".BioEssays.38 (3):226–31.doi:10.1002/bies.201500157.PMID 26709929.S2CID 24768724.
  9. ^Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M (Oct 2002)."Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins".Molecular and Cellular Biology.22 (19):6809–19.doi:10.1128/MCB.22.19.6809-6819.2002.PMC 134047.PMID 12215538.

Further reading

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