This gene encodes a member of theproline andacidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT (July 1992). "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia".Science.257 (5069):531–4.Bibcode:1992Sci...257..531I.doi:10.1126/science.1386162.PMID1386162.
Takahata S, Sogawa K, Kobayashi A, Ema M, Mimura J, Ozaki N, Fujii-Kuriyama Y (July 1998). "Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock".Biochemical and Biophysical Research Communications.248 (3):789–94.Bibcode:1998BBRC..248..789T.doi:10.1006/bbrc.1998.9012.PMID9704006.
Begbie M, Mueller C, Lillicrap D (February 1999). "Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor IX genes".DNA and Cell Biology.18 (2):165–73.doi:10.1089/104454999315556.PMID10073576.
Honda H, Inaba T, Suzuki T, Oda H, Ebihara Y, Tsuiji K, Nakahata T, Ishikawa T, Yazaki Y, Hirai H (May 1999). "Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia".Blood.93 (9):2780–90.doi:10.1182/blood.v93.9.2780.409a47_2780_2790.PMID10216071.
