HLA-C (Human Leukocyte Antigen-C) belongs to the MHCclass I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product andβ2-microglobulin. The mature C chain is anchored in the membrane. MHC Class I molecules, like HLA-C, are expressed in nearly all cells, and present small peptides to the immune system which surveys for non-self peptides.
HLA-C is a locus on chromosome 6, which encodes for many HLA-C alleles that are Class-I MHC receptors. HLA-C, localized proximal to the HLA-B locus, is located on the distal end of the HLA region. Most HLA-C:B haplotypes are in stronglinkage disequilibrium and many are as ancient as the human species itself.
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