The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunitheterodimerictranscription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. At least three transcript variants encoding three different isoforms have been found for this gene.[7]
In rats, it plays a negative role in the adaptation to hypoxia, because the inhibition of HIF-3α expression leads to an increase in physical endurance.[8]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hara S, Hamada J, Kobayashi C, Kondo Y, Imura N (Sep 2001). "Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha".Biochem Biophys Res Commun.287 (4):808–13.Bibcode:2001BBRC..287..808H.doi:10.1006/bbrc.2001.5659.PMID11573933.
^Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, Cao Y, Berkenstam A, Poellinger L (Dec 2001). "Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression".Nature.414 (6863):550–4.Bibcode:2001Natur.414..550M.doi:10.1038/35107085.PMID11734856.S2CID4389117.
Jang MS, Park JE, Lee JA, Park SG, Myung PK, Lee DH, Park BC, Cho S (2005). "Binding and regulation of hypoxia-inducible factor-1 by the inhibitory PAS proteins".Biochem. Biophys. Res. Commun.337 (1):209–15.Bibcode:2005BBRC..337..209J.doi:10.1016/j.bbrc.2005.09.038.PMID16182248.
