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Guanazodine

From Wikipedia, the free encyclopedia

Chemical compound

Pharmaceutical compound

Guanazodine
Clinical data


ATC code	C02CC06 (WHO)
Identifiers
IUPAC name 2-(Azocan-2-ylmethyl)guanidine
CAS Number	32059-15-7
PubChemCID	36054
ChemSpider	33166
UNII	7N05KQ38YI
KEGG	D07169^Y
ChEMBL	ChEMBL2008565
CompTox Dashboard(EPA)	DTXSID30953934
Chemical and physical data
Formula	C₉H₂₀N₄
Molar mass	184.287 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CCCNC(CC1)CNC(=N)N
InChI InChI=1S/C9H20N4/c10-9(11)13-7-8-5-3-1-2-4-6-12-8/h8,12H,1-7H2,(H4,10,11,13) Key:ZCVAIGPGEINFCX-UHFFFAOYSA-N
(verify)

Guanazodine is ananti-hypertensive sympatholytic drug.^[1]^[2]^[3]

References

^Shimizu T, Hamakawa H, Tozuka T, Ono H (October 1976)."[Pharmacological effects of [(octahydro-2-azocinyl)methyl] guanidine(guanazodine): its action mechanism and hypotensive effect]".Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese).72 (7):837–50.doi:10.1254/fpj.72.837.PMID 1035187.
^"Drugbank Online - Guanazodine".
^"National Center for Advancing Translational Sciences".

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Sympatholytic (and closely related)antihypertensives (C02)

Sympatholytics
(antagonizeα-adrenergic
vasoconstriction)

Central

α₂-Adrenergic receptor agonists	Clonidine Guanabenz Guanfacine Guanoxabenz Methyldopa^# Tiamenidine^‡
Adrenergic release inhibitors	Bethanidine Bretylium Debrisoquine Guanadrel Guanazodine Guancydine Guanethidine Guanoclor Guanoxan
Imidazoline receptor agonists	Moxonidine Rilmenidine Tolonidine
Ganglion-blocking/nicotinic antagonists	Hexamethonium^‡ Mecamylamine Pentolinium Trimethaphan

Peripheral

Indirect

Monoamine oxidase inhibitors	Pargyline^‡
VMAT inhibitors	Bietaserpine Deserpidine Methoserpidine Reserpine Syrosingopine
Tyrosine hydroxylase inhibitors	Metirosine

Direct

α₁-Adrenergic receptor blockers	Doxazosin Ketanserin Indoramin Prazosin Trimazosin Urapidil
Non-selective α-adrenergic receptor blockers	Phentolamine

Otherantagonists

Serotonin receptor antagonists	Ketanserin Lidanserin
Endothelin receptor antagonists (for PHTooltip Pulmonary hypertension)	dual (Aprocitentan,Bosentan,Macitentan (+tadalafil),Riociguat) selective (Ambrisentan (+tadalafil),Sitaxentan,Sotatercept)

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

Thisantihypertensive-related article is astub. You can help Wikipedia byexpanding it.

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