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Growth-hormone-releasing hormone receptor

From Wikipedia, the free encyclopedia
Receptor protein that binds with somatcrinin
GHRHR
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

2XDG

Identifiers
AliasesGHRHR, GHRFR, GRFR, IGHD1B, growth hormone releasing hormone receptor, IGHD4
External IDsOMIM:139191;MGI:95710;HomoloGene:640;GeneCards:GHRHR;OMA:GHRHR - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for GHRHR
Genomic location for GHRHR
Band7p14.3Start30,938,669bp[1]
End30,993,254bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for GHRHR
Genomic location for GHRHR
Band6 B3|6 27.38 cMStart55,353,280bp[2]
End55,365,515bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pituitary gland

  • anterior pituitary

  • oocyte

  • secondary oocyte

  • hypothalamus

  • cingulate gyrus

  • anterior cingulate cortex

  • amygdala

  • Descending thoracic aorta

  • nucleus accumbens
Top expressed in
  • pituitary gland

  • anterior pituitary

  • choroid plexus of fourth ventricle

  • entorhinal cortex

  • CA3 field

  • soleus muscle

  • proximal tubule

  • right kidney

  • yolk sac

  • tibialis anterior muscle
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2692

14602

Ensembl

ENSG00000106128

ENSMUSG00000004654

UniProt

Q02643

P32082

RefSeq (mRNA)

NM_000823
NM_001009824

NM_001003685

RefSeq (protein)

NP_000814

NP_001003685

Location (UCSC)Chr 7: 30.94 – 30.99 MbChr 6: 55.35 – 55.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thegrowth-hormone-releasing hormone receptor (GHRHR) is aG-protein-coupled receptor that bindsgrowth hormone-releasing hormone. The GHRHR activates aGs protein that causes a cascade ofcAMP viaadenylate cyclase.[5] GHRHR is distinct from thegrowth hormone secretagogue receptor (also known as the ghrelin receptor), where growth hormone releasing peptides act to release growth hormone.

Function

[edit]

This gene, expressed in the pituitary, encodes a receptor for growth-hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release ofgrowth hormone. Mutations in this gene have been associated with isolated growth-hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptionalsplice variants encoding different isoforms have been described, but only two have been characterized to date.[6]

Ligands

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Agonists

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Antagonists

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References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000106128Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000004654Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Gaylinn BD (2002)."Growth hormone releasing hormone receptor".Receptors & Channels.8 (3–4):155–62.doi:10.1080/10606820213679.PMID 12529933.
  6. ^"Entrez Gene: GHRHR growth hormone releasing hormone receptor".
  7. ^Kovács M, Schally AV, Zarándi M, Groot K (1997). "Inhibition of GH release of rats by new potent antagonists of growth hormone-releasing hormone (GH-RH)".Peptides.18 (3):431–8.doi:10.1016/S0196-9781(96)00334-8.PMID 9145432.S2CID 24368945.
  8. ^Banks WA, Morley JE, Farr SA, Price TO, Ercal N, Vidaurre I, Schally AV (Dec 2010)."Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice".Proceedings of the National Academy of Sciences of the United States of America.107 (51):22272–7.Bibcode:2010PNAS..10722272B.doi:10.1073/pnas.1016369107.PMC 3009756.PMID 21135231.

Further reading

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External links

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This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Neurotransmitter
Adrenergic
Purinergic
Serotonin
Other
Metabolites and
signaling molecules
Eicosanoid
Other
Peptide
Neuropeptide
Other
Miscellaneous
Taste, bitter
Orphan
Other
Adhesion
Orphan
Other
Taste, sweet
Other
Frizzled
Smoothened
GH
(somatotropin)
GHIH
(somatostatin)
GHRH
(somatocrinin)
GHS
(ghrelin)
IGF-1
(somatomedin)
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