
Grapefruit juice is thejuice fromgrapefruits. It is rich invitamin C and ranges from sweet-tart to very sour. Variations include white grapefruit, pink grapefruit and ruby red grapefruit juice.[1][2]
Grapefruit juice is important in medicine because of itsinteractions with many common drugs includingcaffeine and medications, which can alter how they behave in the body.
Grapefruit juice is a common breakfast beverage in the United States.[3]
Grapefruit and grapefruit juice have been found tointeract with numerousdrugs, in many cases resulting in adverse effects.[4] This happens in two ways: one is that grapefruit can block anenzyme whichmetabolizes medication,[5] and if the drug is not metabolized, then the level of the drug in the blood can become too high, leading to anadverse effect.[5] The other effect is that grapefruit can block the absorption of drugs in the intestine,[5] and if the drug is not absorbed, then not enough of it is in the blood to have a therapeutic effect.[5]
One whole grapefruit or a glass of 200 mL (6.8 US fl oz) of grapefruit juice can cause drug overdose toxicity.[4] Drugs which are incompatible with grapefruit are typically labeled on the container orpackage insert.[5] People taking drugs can ask theirhealth care provider orpharmacist questions about grapefruit/drug interactions.[5]
Grapefruit juice is used in severalcocktails, such as thesea breeze (which consists of grapefruit juice, vodka, andcranberry juice);[6] thesalty dog,[7] the grapefruitmimosa,[7] and a grapefruitradler.[8]
Canadian regulations on commercially produced and sold grapefruit juice are that it must be made from clean, mature grapefruit and may contain sugar,invert sugar, dextrose, glucose solids and class II preservatives[9] such as benzoic acid, amylase, cellulase and pectinase.[10] According to Canadian standards, grapefruit juice should contain more than 1.15 milliequivalents of free amino acid per 100 millilitres (3.5 imp fl oz; 3.4 US fl oz); more than 70 milligrams of potassium per 100 ml; and have an absorbance value for totalpolyphenolics of no less than 0.310.[10] During the production process, the sugar content in the juice, before the addition of sugar, invert sugar, dextrose or glucose solids, should have aBrix reading of no less than 9.3. It must contain 0.7% to 2.1% of acid by weight as anhydrous citric acid.[10]