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Sodium- and chloride-dependent glycine transporter 2

From Wikipedia, the free encyclopedia
(Redirected fromGlycine transporter 2)

Protein-coding gene in the species Homo sapiens
SLC6A5
Identifiers
AliasesSLC6A5, GLYT-2, GLYT2, HKPX3, NET1, Glycine transporter 2, solute carrier family 6 member 5
External IDsOMIM:604159;MGI:105090;HomoloGene:37901;GeneCards:SLC6A5;OMA:SLC6A5 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for SLC6A5
Genomic location for SLC6A5
Band11p15.1Start20,599,594bp[1]
End20,659,285bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for SLC6A5
Genomic location for SLC6A5
Band7|7 B4Start49,559,894bp[2]
End49,613,604bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • testicle

  • superior vestibular nucleus

  • metencephalon

  • cerebellum

  • spinal cord

  • cerebellar cortex

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • left testis
Top expressed in
  • medial vestibular nucleus

  • pontine nuclei

  • spinal cord

  • Gray matter of spinal cord

  • anterior horn of spinal cord

  • deep cerebellar nuclei

  • lumbar subsegment of spinal cord

  • posterior horn of spinal cord

  • gray matter layer of cerebellum

  • neural layer of retina
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9152

104245

Ensembl

ENSG00000165970

ENSMUSG00000039728

UniProt

Q9Y345

Q761V0

RefSeq (mRNA)

NM_004211
NM_001318369

NM_001146013
NM_148931

RefSeq (protein)

NP_001305298
NP_004202

n/a

Location (UCSC)Chr 11: 20.6 – 20.66 MbChr 7: 49.56 – 49.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sodium- and chloride-dependent glycine transporter 2, also known asglycine transporter 2 (GlyT2), is aprotein that in humans is encoded by theSLC6A5gene.[5]

The glycine transporter 2 is a membrane protein which recapturesglycine, a major inhibitory transmitter in thespinal cord andbrainstem. GlyT2 is a specific marker of glycinergic neurons and a member of the Na+ and Cl−-coupled transporter family SLC6. Glycine uptake mediated by GlyT2 is electrogenic, coupled to three Na+ and one Cl− (i.e. two positive charges per glycine). In humans, GlyT2 is encoded by theSLC6A5gene. Inactivation of GlyT2 inknockout mice is lethal during the second post-natal week as the absence of GlyT2 disrupts inhibitory transmission by reducing glycine release. Mutations in SLC6A5 gene are responsible for a presynaptic form ofhyperekplexia, a genetic disease causing increasedstartle reflex. GlyT2 main physiological role is to recapture glycine released in the synaptic cleft and to maintain high glycine concentration in the presynaptic neuron. Therefore, chronic inhibition of GlyT2 will deplete intracellular storage of glycine and limit its accumulation in synaptic vesicles.[5][6]

Inhibitors

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See also

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References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000165970 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000039728 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^abMorrow JA, Collie IT, Dunbar DR, Walker GB, Shahid M, Hill DR (November 1998)."Molecular cloning and functional expression of the human glycine transporter GlyT2 and chromosomal localisation of the gene in the human genome".FEBS Lett.439 (3):334–40.doi:10.1016/S0014-5793(98)01390-8.PMID 9845349.S2CID 82276379.
  6. ^"Entrez Gene: SLC6A5 solute carrier family 6 (neurotransmitter transporter, glycine), member 5".

Further reading

[edit]
By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
(6):
(7):
(8):
(9):
(10):
SLC11–20
(11):
(12):
(13):
(14):
(15):
(16):
(17):
(18):
(19):
(20):
SLC21–30
(21):
(22):
(23):
(24):
(25):
(26):
(27):
(28):
(29):
(30):
SLC31–40
(31):
(32):
(33):
(34):
(35):
(36):
(37):
(38):
(39):
(40):
SLC41–48
(41):
(42):
(43):
(44):
(45):
(46):
(47):
(48):
SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)
Receptor
(ligands)
GlyRTooltip Glycine receptor
NMDARTooltip N-Methyl-D-aspartate receptor
Transporter
(blockers)
GlyT1Tooltip Glycine transporter 1
GlyT2Tooltip Glycine transporter 2


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