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Glibenclamide/metformin

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Combination drug

Pharmaceutical compound

Glibenclamide/metformin
Combination of
Glibenclamide	Sulfonylurea
Metformin	Biguanide
Clinical data
Trade names	Glucovance
AHFS/Drugs.com	Monograph
MedlinePlus	a699055
License data	US DailyMed: Glyburide_and_metformin_hydrochloride
Pregnancy category	AU: C [1]
Routes of administration	By mouth
ATC code	None
Legal status
Legal status	AU: S4 (Prescription only)^[1]^[2]^[3]^[4] US: ℞-only^[5]
Identifiers
CAS Number	338752-31-1
KEGG	D10266

Glibenclamide/metformin, also known as glyburide/metformin and sold under the brand nameGlucovance, is afixed-dose combination anti-diabetic medication used to treattype 2 diabetes.^[6] It containsglibenclamide, asulfonylurea, andmetformin, abiguanide.^[7]

^^a ^b"TGA eBS - Product and Consumer Medicine Information Licence".Archived from the original on 23 March 2022. Retrieved30 April 2022.
^"Search the TGA website".
^"Search the TGA website".
^"Search the TGA website".Archived from the original on 30 April 2022. Retrieved30 April 2022.
^"Glucovance- glyburide and metformin hydrochloride tablet, film coated".DailyMed. 23 April 2012.Archived from the original on 30 April 2022. Retrieved30 April 2022.
^Lamos EM, Stein SA, Davis SN (December 2012). "Combination of glibenclamide-metformin HCl for the treatment of type 2 diabetes mellitus".Expert Opinion on Pharmacotherapy.13 (17):2545–54.doi:10.1517/14656566.2012.738196.PMID 23116560.S2CID 10305382.
^"Glyburide and metformin hydrochloride tablet".DailyMed. 10 June 2020.Archived from the original on 26 February 2021. Retrieved11 August 2020.

"Glyburide mixture with Metformin hydrochloride".Drug Information Portal. U.S. National Library of Medicine. Archived fromthe original on 31 August 2024.

Fast-acting	Insulin aspart Insulin glulisine Insulin lispro
Short-acting	Regular insulin^#
Long-acting	Insulin detemir^# Insulin glargine^# (+lixisenatide) NPH insulin Lente insulin^‡ Ultralente insulin^‡
Ultra-long-acting	Insulin degludec^# (+insulin aspart,+liraglutide) Insulin icodec^† (+semaglutide)
Inhalable	Exubera^‡ Afrezza
Oral	Insulin tregopil^†

Non-insulins

Biguanides	Buformin^‡ Metformin^# Phenformin^‡
TZDs ("-glitazones") andPPAR agonists	Ciglitazone^§ Darglitazone^§ Englitazone^§ Lobeglitazone Netoglitazone^§ Pioglitazone Rivoglitazone^† Rosiglitazone Troglitazone^‡
Dual PPAR agonists	Aleglitazar^† Muraglitazar^§ Saroglitazar Tesaglitazar^§
Amylin analogues andDACRAs	Cagrilintide^§ Pramlintide

Sulfonylureas	1st generation:Acetohexamide Carbutamide Chlorpropamide Glycyclamide Metahexamide Tolazamide Tolbutamide 2nd generation:Glibenclamide (glyburide) Glibornuride Glicaramide Gliclazide^# Glimepiride Glipizide Gliquidone Glisoxepide Glyclopyramide
Meglitinides ("-glinides")	Mitiglinide Nateglinide Repaglinide

GLP1 poly-agonist peptides	Mazdutide (GLP-1/GCGR) Retatrutide^§ (GLP-1/GIP/GCGR) Tirzepatide (GLP-1/GIP)

Other

Aldose reductase inhibitors	Epalrestat Fidarestat^§ Ranirestat^† Tolrestat^‡ Zenarestat^§
Alpha-glucosidase inhibitors	Acarbose Miglitol Voglibose
SGLT2 inhibitors ("-gliflozins")	Canagliflozin Dapagliflozin Empagliflozin^# Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin^§ Sergliflozin^§ Sotagliflozin Tofogliflozin^† Velagliflozin
Other	Benfluorex^‡ Bromocriptine Imeglimin

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