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| Clinical data | |
|---|---|
| Other names | CIBA-31458-Ba; CIBA-31458; Norhydroxy-δ6-progesterone acetate; 6-Dehydro-17α-acetoxy-19-norprogesterone; 17α-Acetoxy-19-norpregn-4,6-diene-3,20-dione |
| Routes of administration | By mouth[1][2] |
| Drug class | Progestogen;Progestogen ester |
| Identifiers | |
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| CAS Number | |
| PubChemCID | |
| ChemSpider | |
| UNII | |
| ECHA InfoCard | 100.224.529 |
| Chemical and physical data | |
| Formula | C22H28O4 |
| Molar mass | 356.462 g·mol−1 |
| 3D model (JSmol) | |
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Gestadienol acetate (developmental code nameCIBA-31458-Ba orCIBA-31458) anorally activeprogestin which was described in the literature in 1967 and was never marketed.[3][1][2][4][5] It has noandrogenic orestrogenic effects.[6] The effects of gestadienol acetate on theendometrium and its generalpharmacology were studied in aclinical trial in women.[2][5] It has also been studied in a clinical trial forbenign prostatic hyperplasia in men, but was ineffective.[6]
Gestadienol acetate, also known as norhydroxy-δ6-progesterone acetate, 6-dehydro-17α-hydroxy-19-norprogesterone 17α-acetate, or 17α-hydroxy-19-norpregn-4,6-diene-3,20-dione 17α-acetate, is asyntheticnorpregnanesteroid and aderivative ofprogesterone.[3] It is specifically a combined derivative of17α-hydroxyprogesterone and19-norprogesterone, or ofgestronol (17α-hydroxy-19-norprogesterone), with anacetateester at the C17α position and adouble bond between the C6 and C7 positions.[3] Gestadienol acetate is the C17αacetateester ofgestadienol.[3]Analogues of gestadienol acetate includealgestone acetophenide (dihydroxyprogesterone acetophenide),demegestone,gestonorone caproate (norhydroxyprogesterone caproate),hydroxyprogesterone acetate,hydroxyprogesterone caproate,nomegestrol acetate,norgestomet, andsegesterone acetate (nestorone).[3]
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