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| Names | |
|---|---|
| Preferred IUPAC name (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-yl trihydrogen diphosphate | |
| Other names geranylgeranyl diphosphate trans-geranylgeranyl diphosphate | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChemSpider |
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| MeSH | geranylgeranyl+pyrophosphate |
| UNII | |
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| Properties | |
| C20H36O7P2 | |
| Molar mass | 450.449 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Geranylgeranyl pyrophosphate is an intermediate in the biosynthesis ofditerpenes and diterpenoids.[1] It is also the precursor tocarotenoids,gibberellins,tocopherols, andchlorophylls.
It is also a precursor togeranylgeranylated proteins, which is its primary use in human cells.[2]
It is formed fromfarnesyl pyrophosphate by the addition of anisoprene unit fromisopentenyl pyrophosphate.
InDrosophila, geranylgeranyl pyrophosphate is synthesised by HMG-CoA encoded by the Columbus gene. Geranylgeranyl pyrophosphate is utilised as a chemoattractant for migratinggerm cells that have traversed themidgutepithelia. The attractant signal is produced at thegonadal precursors, directing the germ cells to these sites, where they will differentiate into eggs andspermatozoa (sperm).
