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| Trade names | Flaxedil |
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| Formula | C30H60N3O3+3 · 3 I− (gallamine triethiodide) C24H45N3O3 (gallamine) |
| Molar mass | 891.529 g/mol (gallamine triethiodide) 423.633 g/mol (gallamine) |
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Gallamine triethiodide (Flaxedil) is anon-depolarising muscle relaxant.[1] It acts by combining with thecholinergic receptor sites inmuscle and competitively blocking the transmitter action ofacetylcholine.[2] Gallamine is a non-depolarising type of blocker as it binds to the acetylcholine receptor but does not have thebiological activity of acetyl choline. Gallamine triethiodide has aparasympatholytic effect on the cardiacvagus nerve, which causestachycardia[3][4] and occasionallyhypertension. Very high doses causehistamine release.[citation needed]. Presence ofiodine in the triethiodide salt makes itradio opaque.
Gallamine triethiodide was commonly used to prevent muscle contractions during surgical procedures, but is now superseded by newneuromuscular blocking drugs with fewerside effects.
It was developed byDaniel Bovet in 1947.[5]
The drug is no longer marketed in the United States, according to the FDA Orange Book.