Protein-coding gene in the species Homo sapiens
Transcription factor IIIA is aprotein that in humans is encoded by theGTF3A gene .[ 5] [ 6]
It was first purified and identified as the first mammalian gene-specific activator byRobert G. Roeder in 1980,[ 7]
The TFIIIA inXenopus zinc finger protein discovered.[ 8]
^a b c GRCh38: Ensembl release 89: ENSG00000122034 –Ensembl , May 2017^a b c GRCm38: Ensembl release 89: ENSMUSG00000016503 –Ensembl , May 2017^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ Arakawa H, Nagase H, Hayashi N, Ogawa M, Nagata M, Fujiwara T, et al. (Jul 1995). "Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA".Cytogenetics and Cell Genetics .70 (3– 4):235– 8.doi :10.1159/000134041 .PMID 7789179 . ^ "Entrez Gene: GTF3A general transcription factor IIIA" .^ Engelke DR, Ng SY, Shastry BS, Roeder RG (Mar 1980). "Specific interaction of a purified transcription factor with an internal control region of 5S RNA genes".Cell .19 (3):717– 28.doi :10.1016/S0092-8674(80)80048-1 .PMID 6153931 .S2CID 23955175 . ^ Bruno M, Mahgoub M, Macfarlan TS (December 2019). "The Arms Race Between KRAB-Zinc Finger Proteins and Endogenous Retroelements and Its Impact on Mammals".Annual Review of Genetics .53 (1).Annual Reviews :393– 416.doi :10.1146/annurev-genet-112618-043717 .PMID 31518518 .S2CID 202572327 . Engelke DR, Ng SY, Shastry BS, Roeder RG (Mar 1980). "Specific interaction of a purified transcription factor with an internal control region of 5S RNA genes".Cell .19 (3):717– 28.doi :10.1016/S0092-8674(80)80048-1 .PMID 6153931 .S2CID 23955175 . Murphy JE, Keen JH (May 1992)."Recognition sites for clathrin-associated proteins AP-2 and AP-3 on clathrin triskelia" .The Journal of Biological Chemistry .267 (15):10850– 5.doi :10.1016/S0021-9258(19)50096-5 PMID 1587861 . Seifart KH, Wang L, Waldschmidt R, Jahn D, Wingender E (January 1989)."Purification of human transcription factor IIIA and its interaction with a chemically synthesized gene encoding human 5 S rRNA" .The Journal of Biological Chemistry .264 (3):1702– 9.doi :10.1016/S0021-9258(18)94243-2 PMID 2912980 . Drew PD, Nagle JW, Canning RD, Ozato K, Biddison WE, Becker KG (July 1995). "Cloning and expression analysis of a human cDNA homologous to Xenopus TFIIIA".Gene .159 (2):215– 8.doi :10.1016/0378-1119(95)00145-V .PMID 7622052 . Moorefield B, Roeder RG (August 1994)."Purification and characterization of human transcription factor IIIA" .The Journal of Biological Chemistry .269 (33):20857– 65.doi :10.1016/S0021-9258(17)31901-4 PMID 8063702 . Fridell RA, Fischer U, Lührmann R, Meyer BE, Meinkoth JL, Malim MH, Cullen BR (April 1996)."Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev" .Proceedings of the National Academy of Sciences of the United States of America .93 (7):2936– 40.Bibcode :1996PNAS...93.2936F .doi :10.1073/pnas.93.7.2936 PMC 39738 PMID 8610146 . Oettel S, Härtel F, Kober I, Iben S, Seifart KH (June 1997)."Human transcription factors IIIC2, IIIC1 and a novel component IIIC0 fulfil different aspects of DNA binding to various pol III genes" .Nucleic Acids Research .25 (12):2440– 7.doi :10.1093/nar/25.12.2440 .PMC 146769 PMID 9171097 . Moreland RJ, Dresser ME, Rodgers JS, Roe BA, Conaway JW, Conaway RC, Hanas JS (May 2000)."Identification of a transcription factor IIIA-interacting protein" .Nucleic Acids Research .28 (9):1986– 93.doi :10.1093/nar/28.9.1986 .PMC 103300 PMID 10756201 . Rao DS, Chang JC, Kumar PD, Mizukami I, Smithson GM, Bradley SV, et al. (November 2001)."Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors" .Molecular and Cellular Biology .21 (22):7796– 806.doi :10.1128/MCB.21.22.7796-7806.2001 .PMC 99949 PMID 11604514 . Hanas JS, Hocker JR, Cheng YG, Lerner MR, Brackett DJ, Lightfoot SA, et al. (January 2002). "cDNA cloning, DNA binding, and evolution of mammalian transcription factor IIIA".Gene .282 (1– 2):43– 52.doi :10.1016/S0378-1119(01)00796-X .PMID 11814676 . Weser S, Riemann J, Seifart KH, Meissner W (May 2003)."Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA gene" .Nucleic Acids Research .31 (9):2408– 16.doi :10.1093/nar/gkg345 .PMC 154231 PMID 12711686 . Pellikainen JM, Ropponen KM, Kataja VV, Kellokoski JK, Eskelinen MJ, Kosma VM (November 2004)."Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in breast cancer with a special reference to activator protein-2, HER2, and prognosis" .Clinical Cancer Research .10 (22):7621– 8.doi :10.1158/1078-0432.CCR-04-1061 PMID 15569994 . Paing MM, Johnston CA, Siderovski DP, Trejo J (April 2006)."Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization" .Molecular and Cellular Biology .26 (8):3231– 42.doi :10.1128/MCB.26.8.3231-3242.2006 .PMC 1446942 PMID 16581796 . Yamashita A, Takada T, Nemoto K, Yamamoto G, Torii R (July 2006). "Transient suppression of PPARgamma directed ES cells into an osteoblastic lineage".FEBS Letters .580 (17):4121– 5.Bibcode :2006FEBSL.580.4121Y .doi :10.1016/j.febslet.2006.06.057 .PMID 16828750 .S2CID 84554520 . Schwartz B, Melnikova VO, Tellez C, Mourad-Zeidan A, Blehm K, Zhao YJ, et al. (June 2007)."Loss of AP-2alpha results in deregulation of E-cadherin and MMP-9 and an increase in tumorigenicity of colon cancer cells in vivo" .Oncogene .26 (28):4049– 58.doi :10.1038/sj.onc.1210193 PMID 17224907 . This article incorporates text from theUnited States National Library of Medicine , which is in thepublic domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4)β-Scaffold factors with minor groove contacts
(0) Other transcription factors
