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GTF2H4

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens

GTF2H4
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

5IY9,5IVW,5IY7,5IY8,5IY6

Identifiers
AliasesGTF2H4, general transcription factor IIH, polypeptide 4, 52kDa, P52, TFB2, TFIIH, general transcription factor IIH subunit 4
External IDsOMIM:601760;MGI:1338799;HomoloGene:7090;GeneCards:GTF2H4;OMA:GTF2H4 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for GTF2H4
Genomic location for GTF2H4
Band6p21.33Start30,908,207bp[1]
End30,914,106bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for GTF2H4
Genomic location for GTF2H4
Band17|17 B1Start35,978,622bp[2]
End35,984,631bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • pituitary gland

  • right hemisphere of cerebellum

  • anterior pituitary

  • left lobe of thyroid gland

  • right lobe of thyroid gland

  • body of uterus

  • tibial arteries

  • right coronary artery

  • apex of heart
Top expressed in
  • thymus

  • otic vesicle

  • otic placode

  • spermatocyte

  • epiblast

  • saccule

  • mandibular prominence

  • abdominal wall

  • maxillary prominence

  • ventricular zone
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2968

14885

Ensembl

ENSG00000213780

ENSMUSG00000001524

UniProt

Q92759

O70422

RefSeq (mRNA)

NM_001517

NM_010364

RefSeq (protein)

NP_001508

NP_034494

Location (UCSC)Chr 6: 30.91 – 30.91 MbChr 17: 35.98 – 35.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

General transcription factor IIH subunit 4 is aprotein that in humans is encoded by theGTF2H4gene.[5][6]

Interactions

[edit]

GTF2H4 has been shown tointeract with:

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000213780Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000001524Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^abMarinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (Apr 1997)."Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH".EMBO J.16 (5):1093–102.doi:10.1093/emboj/16.5.1093.PMC 1169708.PMID 9118947.
  6. ^"Entrez Gene: GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa".
  7. ^abcdeScully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997)."BRCA1 is a component of the RNA polymerase II holoenzyme".Proc. Natl. Acad. Sci. U.S.A.94 (11):5605–10.Bibcode:1997PNAS...94.5605S.doi:10.1073/pnas.94.11.5605.PMC 20825.PMID 9159119.
  8. ^Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (Jul 2004)."A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A".Nat. Genet.36 (7):714–9.doi:10.1038/ng1387.PMID 15220921.

Further reading

[edit]

External links

[edit]
(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous


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