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GTF2E2

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

GTF2E2

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
1D8J,1D8K,5IY9,5IYA,5IYC,5IYB,5IY7,5IY8,5IYD,5IY6

Identifiers

Aliases

GTF2E2, FE, TF2E2, TFIIE-B, TTD6, general transcription factor IIE subunit 2

External IDs

OMIM:189964;MGI:1915403;HomoloGene:37573;GeneCards:GTF2E2;OMA:GTF2E2 - orthologs

Gene location (Human)

Chr.	Chromosome 8 (human)^[1]

Band	8p12	Start	30,578,318bp^[1]
Band	8p12	End	30,658,236bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 A4	Start	34,221,861bp^[2]
Band	8\|8 A4	End	34,267,201bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

body of pancreas

right testis

left testis

Achilles tendon

sperm

gonad

islet of Langerhans

right adrenal gland

right adrenal cortex

stromal cell of endometrium

Top expressed in

otic placode

saccule

spermatid

spermatocyte

otic vesicle

tail of embryo

primitive streak

somite

genital tubercle

abdominal wall

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	DNA binding protein binding RNA binding TFIIH-class transcription factor complex binding RNA polymerase II general transcription initiation factor activity
Cellular component	nucleus transcription factor TFIIE complex nucleoplasm transcription factor TFIID complex cytosol nuclear speck
Biological process	transcription elongation from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated snRNA transcription by RNA polymerase II
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


2961


68153

Ensembl


ENSG00000197265


ENSMUSG00000031585

UniProt


P29084


Q9D902

RefSeq (mRNA)


NM_002095 NM_001348353


NM_001167921 NM_001167922 NM_026584

RefSeq (protein)


NP_002086 NP_001335282


NP_001161393 NP_001161394 NP_080860

Location (UCSC)

Chr 8: 30.58 – 30.66 Mb

Chr 8: 34.22 – 34.27 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

General transcription factor IIE subunit 2 (GTF2E2), also known astranscription initiation factor IIE subunit beta (TFIIE-beta), is aprotein that in humans is encoded by theGTF2E2gene.^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000197265 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000031585 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: general transcription factor IIE".

Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Thérien C, Bergeron D, Bourassa S, Greenblatt J, Chabot B, Poirier GG, Hughes TR, Blanchette M, Price DH, Coulombe B (July 2007)."Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme".Molecular Cell.27 (2):262–74.doi:10.1016/j.molcel.2007.06.027.PMC 4498903.PMID 17643375.
Tanaka A, Watanabe T, Iida Y, Hanaoka F, Ohkuma Y (March 2009)."Central forkhead domain of human TFIIE beta plays a primary role in binding double-stranded DNA at transcription initiation".Genes to Cells.14 (3):395–405.doi:10.1111/j.1365-2443.2008.01278.x.PMID 19210545.S2CID 36600862.
Kang SW, Kuzuhara T, Horikoshi M (April 2000)."Functional interaction of general transcription initiation factor TFIIE with general chromatin factor SPT16/CDC68".Genes to Cells.5 (4):251–63.doi:10.1046/j.1365-2443.2000.00323.x.PMID 10792464.S2CID 33454256.
Langelier MF, Forget D, Rojas A, Porlier Y, Burton ZF, Coulombe B (October 2001)."Structural and functional interactions of transcription factor (TF) IIA with TFIIE and TFIIF in transcription initiation by RNA polymerase II".The Journal of Biological Chemistry.276 (42):38652–7.doi:10.1074/jbc.M106422200.PMC 4492724.PMID 11509574.
Yamamoto S, Watanabe Y, van der Spek PJ, Watanabe T, Fujimoto H, Hanaoka F, Ohkuma Y (January 2001)."Studies of nematode TFIIE function reveal a link between Ser-5 phosphorylation of RNA polymerase II and the transition from transcription initiation to elongation".Molecular and Cellular Biology.21 (1):1–15.doi:10.1128/MCB.21.1.1-15.2001.PMC 86563.PMID 11113176.
Watanabe T, Hayashi K, Tanaka A, Furumoto T, Hanaoka F, Ohkuma Y (April 2003)."The carboxy terminus of the small subunit of TFIIE regulates the transition from transcription initiation to elongation by RNA polymerase II".Molecular and Cellular Biology.23 (8):2914–26.doi:10.1128/mcb.23.8.2914-2926.2003.PMC 152561.PMID 12665589.
Jawhari A, Uhring M, De Carlo S, Crucifix C, Tocchini-Valentini G, Moras D, Schultz P, Poterszman A (May 2006)."Structure and oligomeric state of human transcription factor TFIIE".EMBO Reports.7 (5):500–5.doi:10.1038/sj.embor.7400663.PMC 1479554.PMID 16547462.
Orphanides G, Lagrange T, Reinberg D (November 1996)."The general transcription factors of RNA polymerase II".Genes & Development.10 (21):2657–83.doi:10.1101/gad.10.21.2657.PMID 8946909.
Kim TK, Ebright RH, Reinberg D (May 2000). "Mechanism of ATP-dependent promoter melting by transcription factor IIH".Science.288 (5470):1418–22.Bibcode:2000Sci...288.1418K.doi:10.1126/science.288.5470.1418.PMID 10827951.
Ikeda K, Halle JP, Stelzer G, Meisterernst M, Kawakami K (January 1998)."Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6".Molecular and Cellular Biology.18 (1):10–8.doi:10.1128/mcb.18.1.10.PMC 121442.PMID 9418848.
Holstege FC, Fiedler U, Timmers HT (December 1997)."Three transitions in the RNA polymerase II transcription complex during initiation".The EMBO Journal.16 (24):7468–80.doi:10.1093/emboj/16.24.7468.PMC 1170346.PMID 9405375.
Cirulli ET, Kasperaviciūte D, Attix DK, Need AC, Ge D, Gibson G, Goldstein DB (July 2010)."Common genetic variation and performance on standardized cognitive tests".European Journal of Human Genetics.18 (7):815–20.doi:10.1038/ejhg.2010.2.PMC 2987367.PMID 20125193.
Yu X, Li P, Roeder RG, Wang Z (July 2001)."Inhibition of androgen receptor-mediated transcription by amino-terminal enhancer of split".Molecular and Cellular Biology.21 (14):4614–25.doi:10.1128/MCB.21.14.4614-4625.2001.PMC 87125.PMID 11416139.
Yokomori K, Verrijzer CP, Tjian R (June 1998)."An interplay between TATA box-binding protein and transcription factors IIE and IIA modulates DNA binding and transcription".Proceedings of the National Academy of Sciences of the United States of America.95 (12):6722–7.Bibcode:1998PNAS...95.6722Y.doi:10.1073/pnas.95.12.6722.PMC 22611.PMID 9618479.
Liu L, Ishihara K, Ichimura T, Fujita N, Hino S, Tomita S, Watanabe S, Saitoh N, Ito T, Nakao M (February 2009)."MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity".The Journal of Biological Chemistry.284 (8):5165–74.doi:10.1074/jbc.M807098200.PMID 19106100.
De Graeve F, Bahr A, Chatton B, Kedinger C (March 2000)."A murine ATFa-associated factor with transcriptional repressing activity".Oncogene.19 (14):1807–19.doi:10.1038/sj.onc.1203492.PMID 10777215.
Okamoto T, Yamamoto S, Watanabe Y, Ohta T, Hanaoka F, Roeder RG, Ohkuma Y (July 1998)."Analysis of the role of TFIIE in transcriptional regulation through structure-function studies of the TFIIEbeta subunit".The Journal of Biological Chemistry.273 (31):19866–76.doi:10.1074/jbc.273.31.19866.PMID 9677423.
Festen EA, Stokkers PC, van Diemen CC, van Bodegraven AA, Boezen HM, Crusius BJ, Hommes DW, van der Woude CJ, van der Woude JC, Balschun T, Verspaget HW, Schreiber S, de Jong DJ, Franke A, Dijkstra G, Wijmenga C, Weersma RK (February 2010). "Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk".The American Journal of Gastroenterology.105 (2):395–402.doi:10.1038/ajg.2009.576.PMID 19861958.S2CID 10250290.

v t e PDB gallery
1d8k: SOLUTION STRUCTURE OF THE CENTRAL CORE DOMAIN OF TFIIE BETA 1d8j: SOLUTION STRUCTURE OF THE CENTRAL CORE DOMAIN OF TFIIE BETA

Transcription factors andintracellular receptors

(1) Basic domains

(1.1) Basicleucine zipper (bZIP)

Activating transcription factor
- AATF
- 1
- 2
- 3
- 4
- 5
- 6
- 7
AP-1
- c-Fos
- FOSB
- FOSL1
- FOSL2
- JDP2
- c-Jun
- JUNB
- JunD
BACH
- 1
- 2
BATF
BLZF1
C/EBP
- α
- β
- γ
- δ
- ε
- ζ
CREB
- 1
- 3
- L1
CREM
DBP
DDIT3
GABPA
GCN4
HLF
MAF
- B
- sMaf
  - F
  - G
  - K
NFE
- 2
- L1
- L2
- L3
NFIL3
NRL
NRF
- 1
- 2
- 3
XBP1

(1.2) Basic helix-loop-helix (bHLH)

Group A	AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5 MYF6 NeuroD 1 2 Neurogenins 1 2 3 OLIG 1 2 Paraxis TCF15 Scleraxis SLC LYL1 TAL 1 2 Twist
Group B	FIGLA Myc c-Myc l-Myc n-Myc MXD4 TCF4
Group C bHLH-PAS	AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2
Group D	BHLH 2 3 9 Pho4 ID 1 2 3 4
Group E	HES 1 2 3 4 5 6 7 HEY 1 2 L
Group F bHLH-COE	EBF1

(1.3)bHLH-ZIP

(1.4) NF-1

NFI
- A
- B
- C
- X
SMAD
- R-SMAD
  - 1
  - 2
  - 3
  - 5
  - 9
- I-SMAD
  - 6
  - 7
- 4)

(1.5) RF-X

RFX
- 1
- 2
- 3
- 4
- 5
- 6
- ANK

(1.6) Basic helix-span-helix (bHSH)

AP-2
- α
- β
- γ
- δ
- ε

(2)Zinc finger DNA-binding domains

(2.1)Nuclear receptor(Cys₄)

subfamily 1	Thyroid hormone α β CAR FXR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR
subfamily 2	COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular receptor 2 4 TLX
subfamily 3	Steroid hormone Androgen Estrogen α β Glucocorticoid Mineralocorticoid Progesterone Estrogen related α β γ
subfamily 4	NUR NGFIB NOR1 NURR1
subfamily 5	LRH-1 SF1
subfamily 6	GCNF
subfamily 0	DAX1 SHP

(2.2) Other Cys₄

GATA
- 1
- 2
- 3
- 4
- 5
- 6
MTA
- 1
- 2
- 3
TRPS1

(2.3) Cys₂His₂

General transcription factors
- TFIIA
- TFIIB
- TFIID
- TFIIE
  - 1
  - 2
- TFIIF
- 1
- 2
  - TFIIH
  - 1
  - 2
  - 4
  - 2I
  - 3A
  - 3C1
  - 3C2

ATBF1
BCL
- 6
- 11A
- 11B
CTCF
E4F1
EGR
- 1
- 2
- 3
- 4
ERV3
GFI1
GLI family
- 1
- 2
- 3
- REST
- S1
- S2
- YY1
HIC
- 1
- 2
HIVEP
- 1
- 2
- 3
IKZF
- 1
- 2
- 3
ILF
- 2
- 3
Sp/KLF family
- KLF
  - 1
  - 2
  - 3
  - 4
  - 5
  - 6
  - 7
  - 8
  - 9
  - 10
  - 11
  - 12
  - 13
  - 14
  - 15
  - 17
- SP
  - 1
  - 2
  - 4
  - 7
  - 8
MTF1
MYT1
OSR1
PRDM9
SALL
- 1
- 2
- 3
- 4
TSHZ3
WT1
Zbtb7
- 7A
- 7B
ZBTB
- 11
- 16
- 17
- 20
- 21
- 32
- 33
- 40
zinc finger
- 3
- 7
- 9
- 10
- 19
- 22
- 24
- 33B
- 34
- 35
- 41
- 43
- 44
- 51
- 74
- 143
- 146
- 148
- 165
- 202
- 217
- 219
- 238
- 239
- 259
- 267
- 268
- 281
- 300
- 318
- 330
- 346
- 350
- 365
- 366
- 384
- 423
- 451
- 452
- 471
- 593
- 638
- 644
- 649
- 655
- 804A

(2.4) Cys₆

HIVEP1

(2.5) Alternating composition

AIRE
DIDO1
GRLF1
ING
- 1
- 2
- 4
JARID
- 1A
- 1B
- 1C
- 1D
- 2
JMJD1B

(2.6) WRKY

WRKY

(3)Helix-turn-helixdomains

(3.1)Homeodomain

Antennapedia
ANTP class

protoHOX Hox-like	ParaHox Gsx 1 2 Xlox PDX1 Cdx 1 2 4 extended Hox:Evx1 Evx2 MEOX1 MEOX2 Homeobox A1 A2 A3 A4 A5 A7 A9 A10 A11 A13 B1 B2 B3 B4 B5 B6 B7 B8 B9 B13 C4 C5 C6 C8 C9 C10 C11 C12 C13 D1 D3 D4 D8 D9 D10 D11 D12 D13 GBX1 GBX2 MNX1
metaHOX NK-like	BARHL1 BARHL2 BARX1 BARX2 BSX DBX 1 2 DLX 1 2 3 4 5 6 EMX 1 2 EN 1 2 HHEX HLX LBX1 LBX2 MSX 1 2 NANOG NKX 2-1 2-2 2-3 2-5 3-1 3-2 HMX1 HMX2 HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2

other

ARX
CRX
CUTL1
FHL
- 1
- 2
- 3
HESX1
HOPX
LMX
- 1A
- 1B
NOBOX
TALE
- IRX
  - 1
  - 2
  - 3
  - 4
  - 5
  - 6
  - MKX
- MEIS
  - 1
  - 2
- PBX
  - 1
  - 2
  - 3
- PKNOX
  - 1
  - 2
- SIX
  - 1
  - 2
  - 3
  - 4
  - 5
PHF
- 1
- 3
- 6
- 8
- 10
- 16
- 17
- 20
- 21A
POU domain
- PIT-1
- BRN-3:A
- B
- C
- Octamer transcription factor:1
- 2
- 3/4
- 6
- 7
- 11
SATB2
ZEB
- 1
- 2

(3.2) Paired box

PAX
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
PRRX
- 1
- 2
PROP1
PHOX
- 2A
- 2B
RAX
SHOX
SHOX2
VSX1
VSX2
Bicoid
- GSC
- BICD2
- OTX
  - 1
  - 2
- PITX
  - 1
  - 2
  - 3

(3.3)Fork head /winged helix

E2F
- 1
- 2
- 3
- 4
- 5
FOX proteins
- A1
- A2
- A3
- B1
- B2
- C1
- C2
- D1
- D2
- D3
- D4
- D4L1
- D4L3
- D4L4
- D4L5
- D4L6
- E1
- E3
- F1
- F2
- G1
- H1
- I1
- I2
- I3
- J1
- J2
- J3
- K1
- K2
- L1
- L2
- M1
- N1
- N2
- N3
- N4
- O1
- O3
- O4
- O6
- P1
- P2
- P3
- P4
- Q1
- R1
- R2
- S1

(3.4)Heat shock factors

HSF
- 1
- 2
- 4

(3.5) Tryptophan clusters

ELF
- 2
- 4
- 5
EHF
ELK
- 1
- 3
- 4
ERF
ETS
- 1
- 2
- ERG
- SPIB
ETV
- 1
- 4
- 5
- 6
FLI1
Interferon regulatory factors
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
MYB
MYBL2

(3.6) TEA domain

transcriptional enhancer factor
- 1
- 2
- 3
- 4

(4)β-Scaffold factors with minor groove contacts

(4.1)Rel homology region	NF-κB NFKB1 NFKB2 REL RELA RELB NFAT C1 C2 C3 C4 5
(4.2)STAT	STAT 1 2 3 4 5 6
(4.3) p53-like	p53 p63 p73 family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF
(4.4)MADS box	Mef2 A B C D SRF
(4.6)TATA-binding proteins	TBP TBPL1
(4.7)High-mobility group	BBX HMGB 1 2 3 4 HMGN 1 2 3 4 HNF 1A 1B SOX 1 2 3 4 5 6 8 9 10 11 12 13 14 15 17 18 21 SRY SSRP1 TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4
(4.9) Grainyhead	TFCP2
(4.10) Cold-shock domain	CSDA YBX1
(4.11) Runt	CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1

(0) Other transcription factors

(0.2) HMGI(Y)	HMGA 1 2 HBP1
(0.3)Pocket domain	Rb RBL1 RBL2
(0.5)AP-2/EREBP-related factors	Apetala 2 EREBP B3
(0.6) Miscellaneous	ARID 1A 1B 2 3A 3B 4A CAP IFI 16 35 MLL 2 3 T1 MNDA NFY A B C Rho/Sigma