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GPRC5C

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
GPRC5C
Identifiers
AliasesGPRC5C, RAIG-3, RAIG3, G protein-coupled receptor class C group 5 member C
External IDsOMIM:605949;MGI:1917605;HomoloGene:11099;GeneCards:GPRC5C;OMA:GPRC5C - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for GPRC5C
Genomic location for GPRC5C
Band17q25.1Start74,424,851bp[1]
End74,451,653bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for GPRC5C
Genomic location for GPRC5C
Band11|11 E2Start114,741,978bp[2]
End114,763,443bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • olfactory zone of nasal mucosa

  • mucosa of transverse colon

  • right lobe of thyroid gland

  • cerebellar hemisphere

  • left lobe of thyroid gland

  • right hemisphere of cerebellum

  • body of pancreas

  • body of stomach

  • popliteal artery
Top expressed in
  • lumbar spinal ganglion

  • right kidney

  • genital tubercle

  • tail of embryo

  • proximal tubule

  • inner renal medulla

  • zygote

  • yolk sac

  • muscle of thigh

  • human kidney
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55890

70355

Ensembl

ENSG00000170412

ENSMUSG00000051043

UniProt

Q9NQ84

Q8K3J9

RefSeq (mRNA)

NM_018653
NM_022036
NM_001366261
NM_001366262

NM_001110337
NM_001110338
NM_147217

RefSeq (protein)

NP_061123
NP_071319
NP_001353190
NP_001353191

NP_001103807
NP_001103808
NP_671750

Location (UCSC)Chr 17: 74.42 – 74.45 MbChr 11: 114.74 – 114.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

G-protein coupled receptor family C group 5 member C is aprotein that in humans is encoded by theGPRC5Cgene.[5][6]

Function

[edit]

The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene.[6]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000170412Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000051043Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (Nov 2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)".Genomics.67 (1):8–18.doi:10.1006/geno.2000.6226.PMID 10945465.
  6. ^ab"Entrez Gene: GPRC5C G protein-coupled receptor, family C, group 5, member C".

Further reading

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

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