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GPR88

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
GPR88
Identifiers
AliasesGPR88, STRG, COCPMR, G protein-coupled receptor 88
External IDsOMIM:607468;MGI:1927653;HomoloGene:11104;GeneCards:GPR88;OMA:GPR88 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for GPR88
Genomic location for GPR88
Band1p21.2Start100,538,139bp[1]
End100,542,021bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for GPR88
Genomic location for GPR88
Band3|3 G1Start116,043,303bp[2]
End116,047,152bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • external globus pallidus

  • putamen

  • caudate nucleus

  • nucleus accumbens

  • endothelial cell

  • entorhinal cortex

  • middle temporal gyrus

  • prefrontal cortex

  • right lobe of liver

  • dorsolateral prefrontal cortex
Top expressed in
  • olfactory tubercle

  • globus pallidus

  • nucleus accumbens

  • superior frontal gyrus

  • lateral septal nucleus

  • piriform cortex

  • lumbar subsegment of spinal cord

  • temporal lobe

  • barrel cortex

  • primary visual cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54112

64378

Ensembl

ENSG00000181656

ENSMUSG00000068696

UniProt

Q9GZN0

Q9EPB7

RefSeq (mRNA)

NM_022049

NM_022427

RefSeq (protein)

NP_071332

NP_071872

Location (UCSC)Chr 1: 100.54 – 100.54 MbChr 3: 116.04 – 116.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 88 is aprotein that in humans is encoded by theGPR88gene.[5][6][7][8][9]

Ligands

[edit]
Agonists

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000181656Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000068696Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138 (1–2):171–4.doi:10.1016/0378-1119(94)90802-8.PMID 8125298.
  6. ^Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200 (1–2):149–56.doi:10.1016/S0378-1119(97)00411-3.PMID 9373149.
  7. ^Mizushima K, Miyamoto Y, Tsukahara F, et al. (2001). "A novel G-protein-coupled receptor gene expressed in striatum".Genomics.69 (3):314–21.doi:10.1006/geno.2000.6340.PMID 11056049.
  8. ^Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
  9. ^Van Waes V, Tseng K, Steiner H (2011)."GPR88 - a putative signaling molecule predominantly expressed in the striatum: Cellular localization and developmental regulation".Basal Ganglia.1 (2):83–89.doi:10.1016/j.baga.2011.04.001.PMC 3144573.PMID 21804954.
  10. ^Rahman MT, Decker AM, Ben Hamida S, Perrey DA, Chaminda Lakmal HH, Maitra R, Darcq E, Kieffer BL, Jin C (Feb 2023)."Improvement of the Metabolic Stability of GPR88 Agonist RTI-13951-33: Design, Synthesis, and Biological Evaluation".J Med Chem.66 (4):2964–2978.doi:10.1021/acs.jmedchem.2c01983.PMC 9974843.PMID 36749855.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Neurotransmitter
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signaling molecules
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