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GPR83

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

GPR83

Identifiers

Aliases

GPR83, GIR, GPR72, G protein-coupled receptor 83

External IDs

OMIM:605569;MGI:95712;HomoloGene:7732;GeneCards:GPR83;OMA:GPR83 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q21	Start	94,377,316bp^[1]
Band	11q21	End	94,401,419bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9 A2\|9 4.4 cM	Start	14,771,506bp^[2]
Band	9 A2\|9 4.4 cM	End	14,782,085bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cerebellar vermis

middle temporal gyrus

cerebellar hemisphere

right hemisphere of cerebellum

Brodmann area 23

testicle

superior frontal gyrus

spinal ganglia

prefrontal cortex

entorhinal cortex

Top expressed in

olfactory tubercle

nucleus accumbens

pectoral muscles

pectoralis minor muscle

pectoralis major

mammillary body

lobe of prostate

globus pallidus

superior frontal gyrus

lumbar subsegment of spinal cord

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	neuropeptide Y receptor activity G protein-coupled receptor activity signal transducer activity
Cellular component	integral component of membrane plasma membrane membrane non-motile cilium cilium
Biological process	response to glucocorticoid neuropeptide signaling pathway signal transduction G protein-coupled receptor signaling pathway
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


10888


14608

Ensembl


ENSG00000123901


ENSMUSG00000031932

UniProt


Q9NYM4


P30731

RefSeq (mRNA)


NM_016540 NM_001330345


NM_010287 NM_001310734

RefSeq (protein)


NP_001317274 NP_057624


NP_001297663 NP_034417

Location (UCSC)

Chr 11: 94.38 – 94.4 Mb

Chr 9: 14.77 – 14.78 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Probable G-protein coupled receptor 83 is aprotein that in humans is encoded by theGPR83gene.^[5]^[6]^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000123901 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000031932 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Parker R, Liu M, Eyre HJ, Copeland NG, Gilbert DJ, Crawford J,Sutherland GR, Jenkins NA, Herzog H (Jul 2000). "Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6".Biochim Biophys Acta.1491 (1–3):369–75.doi:10.1016/s0167-4781(00)00023-3.PMID 10760605.
^De Moerlooze L, Williamson J, Liners F, Perret J, Parmentier M (Nov 2000). "Cloning and chromosomal mapping of the mouse and human genes encoding the orphan glucocorticoid-induced receptor (GPR83)".Cytogenet Cell Genet.90 (1–2):146–50.doi:10.1159/000015650.PMID 11060465.S2CID 8439947.
^"Entrez Gene: GPR83 G protein-coupled receptor 83".

Nagase T, Kikuno R, Ishikawa K, et al. (2000)."Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro".DNA Res.7 (2):143–50.doi:10.1093/dnares/7.2.143.PMID 10819331.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Hansen W, Loser K, Westendorf AM, et al. (2006)."G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo".J. Immunol.177 (1):209–15.doi:10.4049/jimmunol.177.1.209.PMID 16785516.

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F:Frizzled &Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

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