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GPR157

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

GPR157

Identifiers

Aliases

GPR157, G protein-coupled receptor 157

External IDs

MGI:2442046;HomoloGene:18573;GeneCards:GPR157;OMA:GPR157 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p36.22	Start	9,100,305bp^[1]
Band	1p36.22	End	9,129,102bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 E2	Start	150,171,822bp^[2]
Band	4\|4 E2	End	150,190,384bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

vastus lateralis muscle

skin of arm

gums

gingival epithelium

Skeletal muscle tissue of biceps brachii

oral cavity

Skeletal muscle tissue of rectus abdominis

skin of thigh

tibialis anterior muscle

nasal epithelium

Top expressed in

muscle of thigh

quadriceps femoris muscle

muscle tissue

skeletal muscle tissue

granulocyte

heart

zone of skin

yolk sac

esophagus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transmembrane signaling receptor activity signal transducer activity G protein-coupled receptor activity
Cellular component	integral component of membrane plasma membrane membrane ciliary membrane cell projection
Biological process	cell surface receptor signaling pathway signal transduction G protein-coupled receptor signaling pathway circadian behavior positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway radial glial cell differentiation multicellular organism development cell differentiation
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


80045


269604

Ensembl


ENSG00000180758


ENSMUSG00000047875

UniProt


Q5UAW9


Q8C206

RefSeq (mRNA)


NM_024980


NM_177366

RefSeq (protein)


NP_079256


NP_796340

Location (UCSC)

Chr 1: 9.1 – 9.13 Mb

Chr 4: 150.17 – 150.19 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Probable G-protein coupled receptor 157 is aprotein that in humans is encoded by theGPR157gene.^[5]^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000180758 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000047875 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Jan 2000)."Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain".DNA Res.6 (5):329–36.doi:10.1093/dnares/6.5.329.PMID 10574461.
^"Entrez Gene: GPR157 G protein-coupled receptor 157".

Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006)."The DNA sequence and biological annotation of human chromosome 1".Nature.441 (7091):315–21.Bibcode:2006Natur.441..315G.doi:10.1038/nature04727.PMID 16710414.
Takeo Y, Kurabayashi N, Nguyen MD, Sanada K, et al. (2016)."The G protein-coupled receptor GPR157 regulates neuronal differentiation of radial glial progenitors through the Gq-IP3 pathway".Scientific Reports.6:25180–92.Bibcode:2016NatSR...625180T.doi:10.1038/srep25180.PMC 4855140.PMID 27142930.

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F:Frizzled &Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

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