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GNGT1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens

GNGT1
Identifiers
AliasesGNGT1, GNG1, G protein subunit gamma transducin 1, HG3G1
External IDsOMIM:189970;MGI:109165;HomoloGene:7738;GeneCards:GNGT1;OMA:GNGT1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for GNGT1
Genomic location for GNGT1
Band7q21.3Start93,591,573bp[1]
End93,911,265bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for GNGT1
Genomic location for GNGT1
Band6|6 A1Start3,993,792bp[2]
End3,997,436bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • retinal pigment epithelium

  • buccal mucosa cell

  • testicle

  • gonad

  • placenta

  • paraflocculus of cerebellum

  • amniotic fluid

  • Epithelium of choroid plexus

  • monocyte

  • thymus
Top expressed in
  • neural layer of retina

  • retinal pigment epithelium

  • epithelium of lens

  • pineal gland

  • lumbar subsegment of spinal cord

  • lumbar spinal ganglion

  • ciliary body

  • iris

  • internal carotid artery

  • external carotid artery
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2792

14699

Ensembl

ENSG00000127928

ENSMUSG00000029663

UniProt

P63211

Q61012

RefSeq (mRNA)

NM_021955
NM_001329426

NM_010314

RefSeq (protein)

NP_001316355
NP_068774

NP_034444

Location (UCSC)Chr 7: 93.59 – 93.91 MbChr 6: 3.99 – 4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide-binding protein G(T) subunit gamma-T1 is aprotein that in humans is encoded by theGNGT1gene.[5][6] Either GNGT1 orGNGT2 is thegamma subunit (Gγ) of theGβγ part oftransducin (written G(T) or Gt), aheterotrimeric G-protein naturallyexpressed invertebrateretinarod andcone cells. GNGT1 only occurs in rod cells, and GNGT2 only occurs in cone cells, with a differentalpha (Gα) subunit.[7][8]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000127928 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000029663 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Scherer SW, Feinstein DS, Oliveira L, Tsui LC, Pittler SJ (Sep 1996). "Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin gamma-subunit gene (GNGT1)".Genomics.35 (1):241–3.doi:10.1006/geno.1996.0346.PMID 8661128.
  6. ^"Entrez Gene: GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1".
  7. ^Lagman D, Sundström G, Ocampo Daza D, Abalo XM, Larhammar D (2012)."Expansion of transducin subunit gene families in early vertebrate tetraploidizations".Genomics.100 (4):203–211.doi:10.1016/j.ygeno.2012.07.005.PMID 22814267.
  8. ^Lerea CL, Somers DE, Hurley JB, Klock IB, Bunt-Milam AH (October 1986). "Identification of specific transducin alpha subunits in retinal rod and cone photoreceptors".Science.234 (4772):77–80.Bibcode:1986Sci...234...77L.doi:10.1126/science.3529395.PMID 3529395.

Further reading

[edit]

External links

[edit]
  • Overview of all the structural information available in thePDB forUniProt:P02698 (Bovine Guanine nucleotide-binding protein G(T) subunit gamma-T1) at thePDBe-KB.
PDB gallery
  • 1a0r: HETEROTRIMERIC COMPLEX OF PHOSDUCIN/TRANSDUCIN BETA-GAMMA
    1a0r: HETEROTRIMERIC COMPLEX OF PHOSDUCIN/TRANSDUCIN BETA-GAMMA
  • 1b9x: STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN
    1b9x: STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN
  • 1b9y: STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN BETA-GAMMA
    1b9y: STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN BETA-GAMMA
  • 1got: HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS
    1got: HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS
  • 1tbg: BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN
    1tbg: BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN
  • 2trc: PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX
    2trc: PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX
MAP
Calcium
G protein
Heterotrimeric
cAMP:
cGMP:
Monomeric
Cyclin
Lipid
Otherprotein kinase
Serine/threonine:
Tyrosine:
Serine/threonine/tyrosine
Arginine
Otherprotein phosphatase
Serine/threonine:
Tyrosine:
both:
Apoptosis
GTP-binding protein regulators
Other


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