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GNG13

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

GNG13

Identifiers

Aliases

GNG13, G(gamma)13, h2-35, G protein subunit gamma 13, HG3J

External IDs

OMIM:607298;MGI:1925616;HomoloGene:81890;GeneCards:GNG13;OMA:GNG13 - orthologs

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16p13.3	Start	798,041bp^[1]
Band	16p13.3	End	800,734bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17\|17 A3.3	Start	25,936,145bp^[2]
Band	17\|17 A3.3	End	25,938,380bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right hemisphere of cerebellum

lateral nuclear group of thalamus

right frontal lobe

gonad

anterior cingulate cortex

Brodmann area 9

mucosa of transverse colon

prefrontal cortex

primary visual cortex

Amygdala

Top expressed in

olfactory epithelium

lobe of cerebellum

neural layer of retina

cerebellar vermis

deep cerebellar nuclei

visual cortex

primary visual cortex

superior frontal gyrus

dentate gyrus of hippocampal formation granule cell

Temporal Lobe

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	G-protein beta-subunit binding signal transducer activity GTPase activity
Cellular component	plasma membrane dendrite membrane heterotrimeric G-protein complex
Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway sensory perception of taste signal transduction
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


51764


64337

Ensembl


ENSG00000127588


ENSMUSG00000025739

UniProt


Q9P2W3


Q9JMF3

RefSeq (mRNA)


NM_016541


NM_022422 NM_001357782

RefSeq (protein)


NP_057625


NP_071867 NP_001344711

Location (UCSC)

Chr 16: 0.8 – 0.8 Mb

Chr 17: 25.94 – 25.94 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 is aprotein that in humans is encoded by theGNG13gene.^[5]^[6]

Interactions

[edit]

GNG13 has been shown tointeract withGNB5.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000127588 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000025739 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Huang L, Shanker YG, Dubauskaite J, Zheng JZ, Yan W, Rosenzweig S, Spielman AI, Max M, Margolskee RF (Jan 2000). "Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium".Nat Neurosci.2 (12):1055–62.doi:10.1038/15981.PMID 10570481.S2CID 24494794.
^"Entrez Gene: GNG13 guanine nucleotide binding protein (G protein), gamma 13".
^Blake BL, Wing MR, Zhou JY, Lei Q, Hillmann JR, Behe CI, Morris RA, Harden TK, Bayliss DA, Miller RJ, Siderovski DP (Dec 2001)."G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13)".J. Biol. Chem.276 (52):49267–74.doi:10.1074/jbc.M106565200.PMID 11675383.

Bonaldo MF, Lennon G, Soares MB (1997)."Normalization and subtraction: two approaches to facilitate gene discovery".Genome Res.6 (9):791–806.doi:10.1101/gr.6.9.791.PMID 8889548.
Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (2001)."Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16".Hum. Mol. Genet.10 (4):339–52.doi:10.1093/hmg/10.4.339.PMID 11157797.
Blake BL, Wing MR, Zhou JY, Lei Q, Hillmann JR, Behe CI, Morris RA, Harden TK, Bayliss DA, Miller RJ, Siderovski DP (2002)."G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13)".J. Biol. Chem.276 (52):49267–74.doi:10.1074/jbc.M106565200.PMID 11675383.
Huang L, Max M, Margolskee RF, Su H, Masland RH, Euler T (2003). "G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells".J. Comp. Neurol.455 (1):1–10.doi:10.1002/cne.10396.PMID 12454992.S2CID 22270368.
Cuello F, Schulze RA, Heemeyer F, Meyer HE, Lutz S, Jakobs KH, Niroomand F, Wieland T (2003)."Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta".J. Biol. Chem.278 (9):7220–6.doi:10.1074/jbc.M210304200.PMID 12486123.
Kato C, Mizutani T, Tamaki H, Kumagai H, Kamiya T, Hirobe A, Fujisawa Y, Kato H, Iwasaki Y (2004)."Characterization of heterotrimeric G protein complexes in rice plasma membrane".Plant J.38 (2):320–31.doi:10.1111/j.1365-313X.2004.02046.x.PMID 15078334.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006)."Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes".Genome Res.16 (1):55–65.doi:10.1101/gr.4039406.PMC 1356129.PMID 16344560.
Li Z, Benard O, Margolskee RF (2006)."Ggamma13 interacts with PDZ domain-containing proteins".J. Biol. Chem.281 (16):11066–73.doi:10.1074/jbc.M600113200.PMID 16473877.

Intracellular signaling peptides and proteins

MAP

seeMAP kinase pathway

Calcium

G protein

Heterotrimeric

cAMP:	Heterotrimeric G protein Gs/Gi Adenylate cyclase cAMP 3',5'-cyclic-AMP phosphodiesterase Protein kinase A
cGMP:	Transducin Gustducin Guanylate cyclase cGMP 3',5'-cyclic-GMP phosphodiesterase Protein kinase G
G alpha subunit G_α GNAO1 GNAI1 GNAI2 GNAI3 GNAT1 GNAT2 GNAT3 GNAZ GNAS GNAL GNAQ GNA11 GNA12 GNA13 GNA14 GNA15/GNA16
G beta-gamma complex G_β GNB1 GNB2 GNB3 GNB4 GNB5 G_γ GNGT1 GNGT2 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG10 GNG11 GNG12 GNG13 BSCL2
G protein-coupled receptor kinase AMP-activated protein kinase

Monomeric

Cyclin

Lipid

Otherprotein kinase

Serine/threonine:	Casein kinase 1 2 eIF-2 kinase EIF2AK3 Glycogen synthase kinase GSK1 GSK2 GSK-3 GSK3A GSK3B IκB kinase CHUK IKK2 IKBKG Interleukin-1 receptor associated kinase IRAK1 IRAK2 IRAK3 IRAK4 Lim kinase LIMK1 LIMK2 p21-activated kinases PAK1 PAK2 PAK3 PAK4 Rho-associated protein kinase ROCK1 ROCK2 Ribosomal s6 kinase RPS6KA1
Tyrosine:	ZAP70 Focal adhesion protein-tyrosine kinase PTK2 PTK2B BTK
Serine/threonine/tyrosine	Dual-specificity kinase DYRK1A DYRK1B DYRK2 DYRK3 DYRK4
Arginine	Arginine kinase McsB

Otherprotein phosphatase

Serine/threonine:	Protein phosphatase 2
Tyrosine:	protein tyrosine phosphatase:Receptor-like protein tyrosine phosphatase Sh2 domain-containing protein tyrosine phosphatase
both:	Dual-specificity phosphatase