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GNG11

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

GNG11

Identifiers

Aliases

GNG11, GNGT11, G protein subunit gamma 11, HG3H1

External IDs

OMIM:604390;MGI:1913316;HomoloGene:3045;GeneCards:GNG11;OMA:GNG11 - orthologs

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7q21.3	Start	93,921,735bp^[1]
Band	7q21.3	End	93,928,610bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6\|6 A1	Start	4,003,904bp^[2]
Band	6\|6 A1	End	4,008,445bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

retinal pigment epithelium

tendon of biceps brachii

periodontal fiber

monocyte

stromal cell of endometrium

lactiferous duct

germinal epithelium

seminal vesicula

parietal pleura

placenta

Top expressed in

decidua

blood

right lung

optic nerve

right lung lobe

left lung

left lung lobe

body of femur

internal carotid artery

external carotid artery

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	signal transducer activity GTPase activity protein binding G-protein beta-subunit binding
Cellular component	plasma membrane membrane heterotrimeric G-protein complex G-protein beta/gamma-subunit complex
Biological process	G protein-coupled receptor signaling pathway signal transduction
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


2791


66066

Ensembl


ENSG00000127920


ENSMUSG00000032766

UniProt


P61952


P61953

RefSeq (mRNA)


NM_004126


NM_025331

RefSeq (protein)


NP_004117


NP_079607

Location (UCSC)

Chr 7: 93.92 – 93.93 Mb

Chr 6: 4 – 4.01 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 is aprotein that in humans is encoded by theGNG11gene.^[5]^[6]

This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes alipid-anchored, cell membrane protein.

As a member of theheterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject tocarboxyl-terminal processing. Decreased expression of this gene is associated withsplenic marginal zone lymphomas.^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000127920 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000032766 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ray K, Kunsch C, Bonner LM, Robishaw JD (Oct 1995)."Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits".J Biol Chem.270 (37):21765–71.doi:10.1074/jbc.270.37.21765.PMID 7665596.
^^a ^b"Entrez Gene: GNG11 guanine nucleotide binding protein (G protein), gamma 11".

Downes GB, Gautam N (2000). "The G protein subunit gene families".Genomics.62 (3):544–52.doi:10.1006/geno.1999.5992.PMID 10644457.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999)."Toward a complete human genome sequence".Genome Res.8 (11):1097–108.doi:10.1101/gr.8.11.1097.PMID 9847074.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Cuello F, Schulze RA, Heemeyer F, et al. (2003)."Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta".J. Biol. Chem.278 (9):7220–6.doi:10.1074/jbc.M210304200.PMID 12486123.
Scherer SW, Cheung J, MacDonald JR, et al. (2003)."Human chromosome 7: DNA sequence and biology".Science.300 (5620):767–72.Bibcode:2003Sci...300..767S.doi:10.1126/science.1083423.PMC 2882961.PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003)."The DNA sequence of human chromosome 7".Nature.424 (6945):157–64.Bibcode:2003Natur.424..157H.doi:10.1038/nature01782.PMID 12853948.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells".Science.307 (5715):1621–5.Bibcode:2005Sci...307.1621B.doi:10.1126/science.1105776.PMID 15761153.S2CID 39457788.
Ruiz-Ballesteros E, Mollejo M, Rodriguez A, et al. (2005)."Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis".Blood.106 (5):1831–8.doi:10.1182/blood-2004-10-3898.PMID 15914563.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437 (7062):1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID 16189514.S2CID 4427026.
Hossain MN, Sakemura R, Fujii M, Ayusawa D (2007). "G-protein gamma subunit GNG11 strongly regulates cellular senescence".Biochem. Biophys. Res. Commun.351 (3):645–50.doi:10.1016/j.bbrc.2006.10.112.PMID 17092487.

Intracellular signaling peptides and proteins

MAP

seeMAP kinase pathway

Calcium

G protein

Heterotrimeric

cAMP:	Heterotrimeric G protein Gs/Gi Adenylate cyclase cAMP 3',5'-cyclic-AMP phosphodiesterase Protein kinase A
cGMP:	Transducin Gustducin Guanylate cyclase cGMP 3',5'-cyclic-GMP phosphodiesterase Protein kinase G
G alpha subunit G_α GNAO1 GNAI1 GNAI2 GNAI3 GNAT1 GNAT2 GNAT3 GNAZ GNAS GNAL GNAQ GNA11 GNA12 GNA13 GNA14 GNA15/GNA16
G beta-gamma complex G_β GNB1 GNB2 GNB3 GNB4 GNB5 G_γ GNGT1 GNGT2 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG10 GNG11 GNG12 GNG13 BSCL2
G protein-coupled receptor kinase AMP-activated protein kinase

Monomeric

Cyclin

Lipid

Otherprotein kinase

Serine/threonine:	Casein kinase 1 2 eIF-2 kinase EIF2AK3 Glycogen synthase kinase GSK1 GSK2 GSK-3 GSK3A GSK3B IκB kinase CHUK IKK2 IKBKG Interleukin-1 receptor associated kinase IRAK1 IRAK2 IRAK3 IRAK4 Lim kinase LIMK1 LIMK2 p21-activated kinases PAK1 PAK2 PAK3 PAK4 Rho-associated protein kinase ROCK1 ROCK2 Ribosomal s6 kinase RPS6KA1
Tyrosine:	ZAP70 Focal adhesion protein-tyrosine kinase PTK2 PTK2B BTK
Serine/threonine/tyrosine	Dual-specificity kinase DYRK1A DYRK1B DYRK2 DYRK3 DYRK4
Arginine	Arginine kinase McsB

Otherprotein phosphatase

Serine/threonine:	Protein phosphatase 2
Tyrosine:	protein tyrosine phosphatase:Receptor-like protein tyrosine phosphatase Sh2 domain-containing protein tyrosine phosphatase
both:	Dual-specificity phosphatase